丙咪嗪,英文名:Imipramine HCl,CAS:113-52-0,化学式:C19H25ClN2,分子量:316.87,熔点:168-1700C,沸点:377.7°C at 760 mm
113-52-0
丙咪嗪(Imipramine HCl)
CAS: 113-52-0
化学式: C19H25ClN2
| 中文名 | 丙咪嗪 |
| 英文名 | Imipramine HCl |
| 别名 | 咪帕明 丙咪嗪 托弗尼尔 盐酸丙咪嗪 丙咪嗪盐酸 丙咪嗪盐酸盐 盐酸丙咪嗪溶液, 100PPM N,N-二甲基-10,11-二氢-5H-二苯并[b,f]氮杂卓-5-丙胺盐酸盐 |
| 英文别名 | tofranil tofranile Imipramine HCl LABOTEST-BB LT00452014 Imipramine hydrochloride Imipramine Hydrochloride (200 mg) 10,11-Dihydro-N,N-dimithyl-5,H-dibenz[b,f]azepine-5-propanamine 5-(3-dimethylaminopropyl)-10,11-dihydro-5h-dibenz(b,f)azepinehydrochloride 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-N,N-dimethylpropan-1-aminium chloride Imipramine hydrochloride,10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride |
| CAS | 113-52-0 |
| EINECS | 204-030-7 |
| 化学式 | C19H25ClN2 |
| 分子量 | 316.87 |
| InChI | InChI=1/C20H25N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-11,20H,7,12-15H2,1-2H3;1H |
| 熔点 | 168-1700C |
| 沸点 | 377.7°C at 760 mmHg |
| 闪点 | 9℃ |
| 水溶性 | Soluble in water |
| 蒸汽压 | 6.6E-06mmHg at 25°C |
| 溶解度 | H2O: 50 mg/mL |
| PH值 | 4.2～5.2(100g/l,25℃) |
| 存储条件 | 2-8°C |
| 外观 | 结晶 |
| 颜色 | white |
| 最大波长(λmax) | ['260nm(lit.)'] |
| Merck | 14,4920 |
| 物化性质 | 白色结晶性粉末。熔点174-175℃。易溶于水、乙醇，微溶于丙酮，几乎不溶于乙醚。无臭，味苦。遇光渐变色。米帕明碱（[50-49-7]）沸点160℃（13.3Pa）。 |
| 体外研究 | Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine are widely used to treat chronic pain, but the mechanisms are not fully understood. Imipramine (IC 50 =32 nM) and desipramine (IC 50 =160 nM) are found to be potent inhibitors of the human placental serotonin transporter. |
| 体内研究 | Administration of imipramine reverses social avoidance behavior, significantly increasing the interaction time. 24 days of imipramine treatment in RSD mice significantly decreases stress-induced mRNA levels for IL-6 in brain microglia. Chronic mild stress induces a long-term altered gene expression profile in the prefrontal cortex that is partially reverted by imipramine treatment (10mg/kg, i.p.). Chronic imipramine administration alteres the amino acid dynamics in the brain. In the striatum, the concentrations of asparagine, glutamine and methionine are significantly increased by chronic imipramine administration. In the thalamus and hypothalamus, chronic imipramine administration significantly decreased the valine concentration. Imipramine reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-HT neurons and by anti-BDNF treatment. Imipramine also normalizes derangement of ERK/CREB coupling, which leads to induction of BDNF. This suggests a possible interaction between 5-HT and BDNF. Imipramine treatment counteracts the corticosterone administration-induced increase in the reactivity of rat CA3 hippocampal circuitry to the activation of the 5-HT receptor. |
| 危险品标志 | Xn - 有害物品 T - 有毒物品 F - 易燃物品 |
| 风险术语 | R23/25 - 吸入及吞食有毒。 R36/38 - 刺激眼睛和皮肤。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R22 - 吞食有害。 R39/23/24/25 - R23/24/25 - 吸入、皮肤接触及吞食有毒。 R11 - 高度易燃。 |
| 安全术语 | S7 - 保持容器密封。 S16 - 远离火源。 S24 - 避免皮肤接触。 S33 - 采取措施，预防静电发生。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36/37 - 穿戴适当的防护服和手套。 |
| 危险品运输编号 | UN 1230 3/PG 2 |
| WGK Germany | 3 |
| RTECS | HO1925000 |
| TSCA | Yes |
| 海关编号 | 2933995800 |
| 上游原料 | 米帕明 亚氨基二苄 |
113-52-0 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.156 ml | 15.779 ml | 31.559 ml |
| 5 mM | 0.631 ml | 3.156 ml | 6.312 ml |
| 10 mM | 0.316 ml | 1.578 ml | 3.156 ml |
| 5 mM | 0.063 ml | 0.316 ml | 0.631 ml |
113-52-0 - 简介
丙咪嗪是一种有机化合物。以下是关于丙咪嗪的性质、用途、制法和安全信息的介绍：性质：
- 外观：丙咪嗪为白色晶体或结晶粉末。
- 溶解性：丙咪嗪可溶于水和有机溶剂，如乙醇和氯仿。
用途：
- 实验室用途：丙咪嗪可作为稳定剂或催化剂在有机合成中使用。
制法：
- 丙咪嗪可以通过苯基丙酸甲酯和过氯化物反应制得。具体步骤是将苯基丙酸甲酯与过氯化物在碱性条件下反应，生成丙咪嗪的中间体，再经水解反应得到最终产物。
安全信息：
- 丙咪嗪的使用应遵守化学品安全操作规程，避免接触皮肤和眼睛。
- 在操作丙咪嗪时，应戴上适当的个人防护装备，如实验室服、手套和护目镜。
- 避免吸入丙咪嗪的粉尘。如果吸入过多粉尘，应立即远离现场，到空气流通处呼吸新鲜空气。
- 如果丙咪嗪不慎接触到皮肤或眼睛，应立即用大量清水冲洗。如果有不适，应立即就医。
- 丙咪嗪应储存在干燥、阴凉、通风良好的地方，远离火源和氧化剂。
最后更新：2024-04-09 15:16:47
