L-脯氨酸,英文名:L(-)-Proline,CAS:147-85-3,化学式:C5H9NO2,分子量:115.13,密度:1.35,熔点:228 °C (dec.) (lit.),沸点:215.41
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性质
147-85-3
L-脯氨酸(L(-)-Proline)
CAS: 147-85-3
化学式: C5H9NO2
- 本品为针状结晶或斜方结晶。有强甜味，几乎无臭。熔点222℃（分解）。极易溶于水(162. 3%，25℃)，溶于乙醇，不溶于醚和丁醇，易潮解，不易得到结晶。
- 它是含吡咯烷的亚氨基酸，属非必需氨基酸之一。在生物体内，从谷氨酸出发经△' 吡咯啉-5-羧酸合成得，分解则通过与生物合成的逆反应相同的过程转向谷氨酸代谢。在骨胶原等蛋白质中，氨酸残基以羟基化形式（羟脯氨酸）存在。
- 化学法。
- 直接发酵法。
氨基酸类药。为复方氨基酸大输液原料之一。用于营养不良、蛋白质缺乏症、严重肠胃道疾患、烫伤及外科手术后的蛋白质补充。
安全性密封保存。
| 中文名 | L-脯氨酸 |
| 英文名 | L(-)-Proline |
| 别名 | 脯氨酸 L-脯氨酸 依那普利杂质8 (S)-吡咯烷-2-羧酸 L-PROLINE L-脯氨酸 脯氨酸 (PRO)溶液,100PPM |
| 英文别名 | Proline H-Pro-OH L-Proline L(-)-Proline L(-)-Proline 0 L-PROLINE, NATURAL L-PROLINE, SYNTHETIC 2-Pyrrolidinecarboxylic acid L-(-)-PROLINE ((S)-(-)-PROLINE) (S)-Pyrrolidine-2-carboxylic acid L-Proline ,L-2-Pyrrolidinecarboxylic acid |
| CAS | 147-85-3 |
| EINECS | 205-702-2 |
| 化学式 | C5H9NO2 |
| 分子量 | 115.13 |
| InChI | InChI=1/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1 |
| InChIKey | ONIBWKKTOPOVIA-UHFFFAOYSA-N |
| 密度 | 1.35 |
| 熔点 | 228 °C (dec.) (lit.) |
| 沸点 | 215.41°C (rough estimate) |
| 比旋光度 | -85.5 º (c=4, H2O) |
| 闪点 | 106.3°C |
| 水溶性 | soluble |
| 蒸汽压 | 0Pa at 25℃ |
| JECFA Number | 1425 |
| 溶解度 | H2O: 50 mg/mL |
| 折射率 | -85 ° (C=4, H2O) |
| 酸度系数 | 1.95, 10.64(at 25℃) |
| PH值 | 6.0-7.0 (25℃, 1M in H2O) |
| 存储条件 | 2-8°C |
| 稳定性 | 稳定。与强氧化剂不相容。 |
| 敏感性 | Hygroscopic |
| 外观 | 粉末 |
| 颜色 | White |
| 最大波长(λmax) | ['λ: 260 nm Amax: 0.05', , 'λ: 280 nm Amax: 0.05'] |
| Merck | 14,7780 |
| BRN | 80810 |
| 物化性质 | 无色结晶，无臭，味甜；易溶于水(25℃水中溶解度为162.3 g/100 ml)和乙醇，不溶于丁醇及乙醚，遇水合茚三酮试液呈黄色，冰乙酸酸化后显红色；pI6.3，分解点为220-222℃；比旋光度[α]20D-85°(0.5-2.0 mg/ml，H2O)，[α]20D-60.4°(0.5-2.0 mg/ml，5 mol/L HCl)。 |
| MDL号 | MFCD00064318 |
| 危险品标志 | Xi - 刺激性物品 Xn - 有害物品 |
| 风险术语 | R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 R22 - 吞食有害。 |
| 安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 |
| WGK Germany | 3 |
| RTECS | TW3584000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| 海关编号 | 29339990 |
| 上游原料 | 无水葡萄糖 |
| 下游产品 | D-脯氨酸 卡托普利 赖诺普利 依那普利 |
| 参考资料 展开查看 | 1. 甘惠玉 黄露. 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147-85-3 - 性质
可信数据
- 本品为针状结晶或斜方结晶。有强甜味，几乎无臭。熔点222℃（分解）。极易溶于水(162. 3%，25℃)，溶于乙醇，不溶于醚和丁醇，易潮解，不易得到结晶。
- 它是含吡咯烷的亚氨基酸，属非必需氨基酸之一。在生物体内，从谷氨酸出发经△' 吡咯啉-5-羧酸合成得，分解则通过与生物合成的逆反应相同的过程转向谷氨酸代谢。在骨胶原等蛋白质中，氨酸残基以羟基化形式（羟脯氨酸）存在。
147-85-3 - 制发
可信数据
- 化学法。
- 直接发酵法。
147-85-3 - 用途
可信数据
氨基酸类药。为复方氨基酸大输液原料之一。用于营养不良、蛋白质缺乏症、严重肠胃道疾患、烫伤及外科手术后的蛋白质补充。
最后更新：2022-01-01 11:10:30147-85-3 - 安全性
可信数据
密封保存。
最后更新：2022-01-01 11:10:30147-85-3 - 简介
L-脯氨酸（L-Proline）是一种非必需氨基酸，具有特殊的性质和用途。以下是关于它的性质，用途，制法和安全信息的介绍：
性质：
1、L-脯氨酸是一种白色结晶性粉末，在水中溶解度较高。
2、它是一种双旋光性分子，可旋转入射线的振动方向。
3、L-脯氨酸是构成蛋白质结构的重要氨基酸之一，也是许多生物过程中重要酶的底物和辅因子。
用途：
作为脯氨酸代谢的组成部分，L-脯氨酸在机体中发挥重要作用，参与胶原蛋白合成、维持肌肉、骨骼和皮肤的健康，以及免疫调节等生理功能。
制法：
L-脯氨酸的制备可通过化学合成或生物合成两种方法实现：
1、化学合成：通过对吡咯烷酮进行环化、加氢还原、水解等步骤，可合成L-脯氨酸。
2、生物合成：利用微生物，如大肠杆菌等，经过改造和发酵工艺，将天然的发酵产生的L-脯氨酸纯化提取得到。
安全信息：
1、L-脯氨酸在一般情况下被认为是安全的，但仍需注意以下事项：
2、长期或大量摄入L-脯氨酸可能引起一些消化系统反应，如腹泻、恶心等症状。
3、如有过敏体质或对L-脯氨酸成分过敏的人，应避免使用。
在使用L-脯氨酸时，请务必遵循医生或专业人士的指导，并注意正确的剂量和用法。
