槐角苷,英文名:4'-beta-D-glucopyranosyloxy-5,7-dihydroxyisoflavone,CAS:152-95-4,化学式:C21H20O10,分子量:432.
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槐角苷具有许多重要的生理活性和药用价值。它具有抗氧化、抗菌、抗炎、抗肿瘤、抗血小板聚集、抗血栓以及降低胆固醇等多种生物活性。
制取槐角苷的常见方法是从槐角(槐树的果实)中提取。首先将槐角研磨成粉末，然后采用溶剂提取的方法，如乙醇或水抽取，最后通过结晶或蒸发溶剂得到纯化的槐角苷。
槐角苷的安全性，目前尚未发现对人体的毒副作用或健康风险。最后更新：2024-04-09 21:54:55
152-95-4
槐角苷(4'-beta-D-glucopyranosyloxy-5,7-dihydroxyisoflavone)
CAS: 152-95-4
化学式: C21H20O10
| 中文名 | 槐角苷 |
| 英文名 | 4'-beta-D-glucopyranosyloxy-5,7-dihydroxyisoflavone |
| 别名 | 槐苷 槐甙 槐属甙 槐角苷 槐角甙 槐属苷(标准品) 槐角苷(分析标准品) 染料木素-4-葡萄糖甙 SOPHORICOSIDE 槐角苷 |
| 英文别名 | ISOGENISTIN sophoricoside SOPHORICOSIDE GENISTEIN-4'-GLUCOSIDE GENISTEIN-4'-O-GLUCOSIDE 4H-1-Benzopyran-4-one,3-[4-(β- D-glucopyranosyloxy)phenyl]-5,7-dihydroxy- 4'-beta-D-glucopyranosyloxy-5,7-dihydroxyisoflavone 4-(5,7-dihydroxy-4-oxo-4H-chromen-3-yl)phenyl beta-D-glucopyranoside 4-(5,7-dihydroxy-4-oxo-4H-chromen-3-yl)phenyl alpha-L-gulopyranoside 5,7-dihydroxy-3-[4-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]phenyl]-1-benzopyran-4-one |
| CAS | 152-95-4 |
| 化学式 | C21H20O10 |
| 分子量 | 432.38 |
| InChI | InChI=1/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-3-1-9(2-4-11)12-8-29-14-6-10(23)5-13(24)16(14)17(12)25/h1-6,8,15,18-24,26-28H,7H2/t15-,18+,19-,20-,21+/m0/s1 |
| 密度 | 1.3597 (rough estimate) |
| 熔点 | 298° |
| 沸点 | 466.08°C (rough estimate) |
| 比旋光度 | D20 -47° (pyridine); D20 -32° (10% aq pyridine) |
| 闪点 | 271.5°C |
| 蒸汽压 | 1.7E-24mmHg at 25°C |
| 溶解度 | 碱水溶液 (微溶)，DMSO (微溶，加热)，吡啶 (微溶，超声处理) |
| 折射率 | 1.5376 (estimate) |
| 酸度系数 | 6.45±0.20(Predicted) |
| 存储条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 外观 | 固体 |
| 颜色 | White to Light Brown |
| 最大波长(λmax) | ['271nm(MeOH)(lit.)'] |
| 物化性质 | 白色结晶粉末，溶于甲醇，来源于槐角。 |
| MDL号 | MFCD01075138 |
| 体外研究 | Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner. |
| 体内研究 | When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent. |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| 海关编号 | 29329990 |
| 上游原料 | UDP-葡萄糖 |
| 参考资料 展开查看 | 1. 牛晓静, 鲁静, 马彦江,等. 基于多指标总评归一法优选槐角炮制工艺[J]. 中华中医药学刊, 2019, v.37(11):59-62. 2. 王开超, 莫颖宁, 贺灵剑. 超声提取-反相中压液相制备高纯度槐角苷的研究. 3. 王开超,莫颖宁,贺灵剑.超声提取-反相中压液相制备高纯度槐角苷的研究[J].山东中医杂志,2020,39(08):868-873. |
152-95-4 - 简介
槐角苷是一种植物次生代谢产物，属于异黄酮类化合物。槐角苷具有许多重要的生理活性和药用价值。它具有抗氧化、抗菌、抗炎、抗肿瘤、抗血小板聚集、抗血栓以及降低胆固醇等多种生物活性。
制取槐角苷的常见方法是从槐角(槐树的果实)中提取。首先将槐角研磨成粉末，然后采用溶剂提取的方法，如乙醇或水抽取，最后通过结晶或蒸发溶剂得到纯化的槐角苷。
槐角苷的安全性，目前尚未发现对人体的毒副作用或健康风险。最后更新：2024-04-09 21:54:55
