4-甲氨基安替比林,英文名:4-Methylamino Antipyrine,CAS:519-98-2,化学式:C12H15N3O,分子量:217.27,密度:1.20±0.1 g/cm3 (20 º

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4-甲氨基安替比林(4-Methylamino Antipyrine)

CAS: 519-98-2

化学式: C12H15N3O

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中文名	4-甲氨基安替比林
英文名	4-Methylamino Antipyrine
别名	咪达唑仑杂质C 4-甲氨基安替比林 4-(甲氨基)安替比林 4-单甲基氨基安替比林 4-(甲基氨基)安替比林 安替比林,4-(甲基氨基)- 2,3-二甲基-4-甲基-1-苯基-3-吡唑啉-5-酮 乙二醇甲酸乙醚1,5-二甲基-4-(甲基氨基)-2-苯基- 1,2-二氢-1,5-二甲基-4-(甲基氨基)-2-苯基-3H-吡唑-3-酮
英文别名	noramidopyrine Noraminopyrine Methylaminoantipyrine 4-Methylamino Antipyrine Monomethylaminoantipyrine 4-(Methylamino)-antipyrine 2,3-Dimethyl-4-methylamino-1-phenyl-3-pyrazolin-5-one 2-(1-cyclohexa-2,4-dienyl)-1,5-dimethyl-4-(methylamino)-3-pyrazolone 1,5-Dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride
CAS	519-98-2
EINECS	208-281-3
化学式	C12H15N3O
分子量	217.27
密度	1.20±0.1 g/cm3 (20 ºC 760 Torr)
熔点	50-53°C
沸点	324.5±45.0 °C(Predicted)
溶解度	氯仿 (微溶) 、乙酸乙酯 (微溶) 、甲醇 (微溶)
酸度系数	4.76±0.20(Predicted)
存储条件	-20°C Freezer
外观	固体
颜色	Pale Yellow to Brown Oil to
物化性质	油状液体。
体外研究	Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important.
体内研究	The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentrations of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine.
Hazard Class	IRRITANT
上游原料	4-氨基安替比林
下游产品	海藻酸铵