N-乙酰-5-羟色胺,英文名:N-acetyl-5-hydroxytryptamine,CAS:1210-83-9,化学式:C12H14N2O2,分子量:218.25,密度:1.268±0.06 g/
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N-乙酰-5-羟色胺在生理上具有调节睡眠、情绪和食欲的作用。它在神经系统中发挥着重要的作用，参与调节情绪、认知和快感。N-乙酰-5-羟色胺也被发现对血管收缩、炎症和血小板聚集具有调节作用。
N-乙酰-5-羟色胺的制法通常通过化学合成得到。一种常用的制备方法是将5-羟色胺与乙酸酐反应，生成N-乙酰-5-羟色胺的乙酸酯。
安全性，N-乙酰-5-羟色胺的毒性数据相对有限。作为一种神经递质衍生物，它可能对神经系统有一定的影响。对于具体的使用和剂量，请遵循相关的科学指导和法规。最后更新：2024-04-09 21:54:55
1210-83-9
N-乙酰-5-羟色胺(N-acetyl-5-hydroxytryptamine)
CAS: 1210-83-9
化学式: C12H14N2O2
| 中文名 | N-乙酰-5-羟色胺 |
| 英文名 | N-acetyl-5-hydroxytryptamine |
| 别名 | 羟色胺杂质5 N-乙酰羟色胺 N-乙酰基血清素 N-乙酰-5-羟色胺 N-乙酰-5-羟基色胺 N-乙酰基-5-羟基色胺 N-(2-(5-羟基-1H-吲哚-3-基)乙基)乙酰胺 |
| 英文别名 | N-Acetyl-5-HT Acetylserotonin N-acetyl-5-hydroxytryptamine N-Acetylserotonin, Normelatonin N-Acetyl-5-hydroxy-1H-indole-3-ethaneamine 3-(2-Acetamidoethyl)-5-hydroxyindoleN-Acetylserotonin N-Acetyl-5-hydroxytryptamine,N-Acetylserotonin, Normelatonin |
| CAS | 1210-83-9 |
| EINECS | 214-916-5 |
| 化学式 | C12H14N2O2 |
| 分子量 | 218.25 |
| InChI | InChI=1/C12H14N2O2/c1-8(15)13-5-4-9-7-14-12-3-2-10(16)6-11(9)12/h2-3,6-7,14,16H,4-5H2,1H3,(H,13,15) |
| 密度 | 1.268±0.06 g/cm3(Predicted) |
| 熔点 | 120-122 °C (lit.) |
| 沸点 | 556.8±40.0 °C(Predicted) |
| 闪点 | 290.6°C |
| 蒸汽压 | 5.25E-13mmHg at 25°C |
| 溶解度 | 乙醇: 50mg/ml |
| 折射率 | 1.651 |
| 酸度系数 | 10.09±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 稳定性 | 吸湿性 |
| 外观 | 粉末 |
| 颜色 | white |
| MDL号 | MFCD00005656 |
| 体外研究 | N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner. |
| 体内研究 | To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation. |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| 海关编号 | 29339900 |
| 上游原料 | 乙醚 二氯甲烷 碳酸钾 三乙胺 氨 吡啶 乙酰氯 5-苄氧基吲哚 |
| 参考资料 展开查看 | 1. [IF=5.64] Gangzheng Wang et al."Biosynthetic Pathway and the Potential Role of Melatonin at Different Abiotic Stressors and Developmental Stages in Tolypocladium guangdongense."Front Microbiol. 2021; 12: 746141 |
1210-83-9 - 简介
N-乙酰-5-羟色胺（N-Acetyl-5-Hydroxytryptamine）是一种有机化合物，也被称为N-乙酰血清素或5-羟色胺N-乙酸酯。它是5-羟色胺（一种重要的神经递质）的衍生物。N-乙酰-5-羟色胺在生理上具有调节睡眠、情绪和食欲的作用。它在神经系统中发挥着重要的作用，参与调节情绪、认知和快感。N-乙酰-5-羟色胺也被发现对血管收缩、炎症和血小板聚集具有调节作用。
N-乙酰-5-羟色胺的制法通常通过化学合成得到。一种常用的制备方法是将5-羟色胺与乙酸酐反应，生成N-乙酰-5-羟色胺的乙酸酯。
安全性，N-乙酰-5-羟色胺的毒性数据相对有限。作为一种神经递质衍生物，它可能对神经系统有一定的影响。对于具体的使用和剂量，请遵循相关的科学指导和法规。最后更新：2024-04-09 21:54:55
