4-雄烯-11β-醇-3,17-二酮,英文名:4-androsten-11B-ol-3,17-dione,CAS:382-44-5,化学式:C19H26O3,分子量:302.41,密度:1.19g/c

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4-雄烯-11β-醇-3,17-二酮(4-androsten-11B-ol-3,17-dione)

CAS: 382-44-5

化学式: C19H26O3

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中文名	4-雄烯-11β-醇-3,17-二酮
英文名	4-androsten-11B-ol-3,17-dione
别名	17-二酮 11Β-羟基雄甾-4-烯-3 4-雄烯-11β-醇-3,17-二酮 4-雄甾烯-11-醇-3,17-二酮 11β-羟基雄甾-4-烯-3,17-二酮 11BETA-羟基-4-雄甾烯-3,17-二酮 4-雄甾烯-11Β-OL-3,17-二酮-2,2,4,6,6,16,16-D7
英文别名	u 2826 4-androsten-11B-ol-3,17-dione 11-BETA-HYDROXYANDROSTENEDIONE 4-ANDROSTEN-11BETA-OL-3,17-DIONE 4-Androstene-11beta-ol-3,17-dione 11-Hydroxyandrost-4-ene-3,17-dione 11beta-Hydroxy-4-androsten-3,17-dione 11BETA-HYDROXY-4-ANDROSTENE-3,17-DIONE Androst-4-ene-3,17-dione, 11beta-hydroxy- Androst-4-ene-3,17-dione, 11-hydroxy-, (11beta)-
CAS	382-44-5
化学式	C19H26O3
分子量	302.41
InChI	InChI=1/C19H26O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-15,17,21H,3-8,10H2,1-2H3/t13-,14-,15-,17+,18-,19-/m0/s1
密度	1.19g/cm3
熔点	197-199℃
沸点	475.3°C at 760 mmHg
闪点	255.4°C
蒸汽压	4.95E-11mmHg at 25°C
折射率	1.569
存储条件	-20℃
MDL号	MFCD00051131
体外研究	In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.
体内研究	The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.
WGK Germany	3
下游产品	肾上腺甾酮

382-44-5 - 介绍

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