异牡荆黄素,英文名:Isovitexin,CAS:38953-85-4,化学式:C21H20O10,分子量:432.38,密度:1.686±0.06 g/cm3(Predicted),熔点:257-2

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38953-85-4 询问

异牡荆黄素(Isovitexin)

CAS: 38953-85-4

化学式: C21H20O10

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中文名	异牡荆黄素
英文名	Isovitexin
别名	异黄链霉素 异牡荆黄素 异牡荆黄素, 来源于山楂树 异牡荆素(UNDER DEVELOPMENT) 4H-1-BENZOPYRAN-4-ONE,6-尾-D-GLUCOPYRANOSYL-5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-
英文别名	C01714 Isovitexin ISOVITEXIN SAPONARETIN HOMOVITEXIN SAPOMARETOM 6-C-Glucosylapigenin APIGENIN-6-C-GLUCOSIDE APIGENIN 6-C-Β-D-GLUCOSIDE Isovitexin, froM Crataegus pinnatifida
CAS	38953-85-4
化学式	C21H20O10
分子量	432.38
密度	1.686±0.06 g/cm3(Predicted)
熔点	257-258 °C
沸点	807.0±65.0 °C(Predicted)
酸度系数	5.93±0.40(Predicted)
存储条件	2-8°C
外观	整洁
BRN	66651
物化性质	淡黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于山楂叶，竹叶，新西兰牡荆 Vitex lucens，滨牡荆 Virex littoralis，皂荚 Gleditsia sinensis [Syn．Gleditsia horrida]，酸角 Tamarindus indica，亚麻 Linum usitatissimum，獐牙菜 Swertia pseudochinensis．。
MDL号	MFCD00076044
体外研究	Isovitexin protects against LPS-induced oxidative damage by suppressing intracellular ROS generation, and also attenuates the effect of H 2 O 2 on cell viability. Isovitexin (0-100 μg/mL) with LPS (2 μg/mL) is not cytotoxic to RAW 264.7 cells, but 200 μg/mL Isovitexin shows significant cytotoxicity. Isovitexin (25, 50 μg/mL) inhibits LPS-induced increases in TNF-α, IL-6, iNOS, and COX-2 levels. Isovitexin (25, 50 μg/mL) also suppresses the IκBα phosphorylation and degradation in RAW 264.7 cells, and such an effect is consistent with that of JNK1/2 inhibitor.
体内研究	Isovitexin (50 and 100 mg/kg, i.p.) causes less severe histopathological changes in the lung sections, and reduces inflammatory cell count in LPS-induced mice. Isovitexin (50 and 100 mg/kg, i.p.) protects against LPS-induced inflammation and oxidative stress in LPS-induced ALI mice by decreasing TNF-α and IL-6 production, ROS generation, and MPO and MDA content, increasing SOD and GSH levels and effectively inhibiting the protein expression of iNOS and COX-2. Isovitexin (25, 50, 100 mg/kg) dose-dependently reduces the survival rate of LPS/D-gal induced hepatic injury in mice. Isovitexin also inhibits NF-κB activation and up-regulates Nrf2 and HO-1 induced by LPS/D-gal in mice.
WGK Germany	3
海关编号	29329990
参考资料 展开查看	1. Xi Juan Zhao, Peng Mei Guo, Wen Hui Pang, Yao Hai Zhang, Qi Yang Zhao, Bi Ning Jiao, Paul A. Kilmartin,A rapid UHPLC-QqQ-MS/MS method for the simultaneous qualitation and quantitation of coumarins, furocoumarins, flavonoids, phenolic acids in pummelo frui 2. [IF=4.162] Jiuling Deng et al."A Network Pharmacology-Based Investigation to the Pharmacodynamic Material Basis and Mechanisms of the Anti-Inflammatory and Anti-Viral Effect of Isatis indigotica."Drug Des Dev Ther. 2021; 15: 3193–3206 3. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

38953-85-4 - 简介

异牡荆黄素，又称黄素酮，是一种天然的有机化合物。它呈黄色晶体或黄色结晶性粉末，不溶于水，几乎不溶于醇类和醚类溶剂，可溶于有机溶剂如氯仿、乙醚和二硫化碳等。

异牡荆黄素有一系列重要的生理活性作用，具有抗氧化、抗菌、抗病毒、抗炎症、抑制肿瘤生长等多种作用。它对光线有很强的吸收能力，可用作染料或增加产品颜色。

制取异牡荆黄素的方法主要有天然提取和化学合成两种。天然提取利用异牡荆黄素丰富的植物资源，如茄科植物锥花黄、辣椒籽、辣椒粉等，通过溶剂浸提和柱色谱分离等工艺得到纯异牡荆黄素。化学合成则采用有机合成方法，通过合成原料经过一系列反应，经过结晶纯化得到异牡荆黄素。

安全信息：异牡荆黄素被认为是相对安全的。在一般使用条件下，异牡荆黄素无毒，但在高浓度下可能具有一定的副作用，如可能引起过敏反应。在使用异牡荆黄素时，需要严格按照指导剂量使用，注意个体对该物质的过敏反应情况。最后更新：2024-04-09 20:48:19