杨芽黄素,英文名:Tectochrysin,CAS:520-28-5,化学式:C16H12O4,分子量:268.26,密度:1.329±0.06 g/cm3(Predicted),熔点:166-168
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性质：杨芽黄素为黄色的结晶性粉末，具有良好的溶解性，可溶于一些有机溶剂。它具有抗氧化、抗菌、抗炎等功效。
它可以提供保护细胞免受自由基损伤的抗氧化功能，对于调节免疫功能、抗衰老、保护皮肤等方面具有积极作用。
制法：通常可以通过从杨树芽中提取杨芽黄素来获得。提取先将杨树芽研磨成粉末状，然后使用适当的溶剂进行浸提，再采用过滤、浓缩和结晶等工艺步骤进行纯化得到杨芽黄素。
安全信息：杨芽黄素通常被认为是一种相对安全的物质，但不排除个别人可能存在过敏反应。对于孕妇、哺乳期妇女和有特殊过敏史的人群，应先咨询专业人士的意见。避免吸入和接触眼睛，如发生不适应立即停止使用。最后更新：2024-04-09 21:11:58
520-28-5
杨芽黄素(Tectochrysin)
CAS: 520-28-5
化学式: C16H12O4
| 中文名 | 杨芽黄素 |
| 英文名 | Tectochrysin |
| 别名 | 柚木柯因 黄芽黄素 柚金黃酮 甲金黃酮 杨芽黄素 杨芽黄素(标准品) 黄芽黄素(杨芽黄素) 杨芽黄素(黄芽黄素) |
| 英文别名 | Techto NSC 80687 Tectochrysin TECTOCHRYSIN METHYL CHRYSIN Techtochrysine CHRYSIN 7-METHYL ETHER 2-Phenyl-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one 7-Methoxy-2-phenyl-5-hydroxy-4H-1-benzopyran-4-one |
| CAS | 520-28-5 |
| 化学式 | C16H12O4 |
| 分子量 | 268.26 |
| 密度 | 1.329±0.06 g/cm3(Predicted) |
| 熔点 | 166-168°C |
| 沸点 | 487.4±45.0 °C(Predicted) |
| 溶解度 | DMSO: 16.67毫克/毫升 (62.14毫米; 需要超声波) |
| 酸度系数 | 6.34±0.40(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 黄色结晶 |
| 物化性质 | 白色针状结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于松属植物Pinus cembra L.的心材中。 |
| MDL号 | MFCD00016945 |
| 体外研究 | Tectochrysin (Techtochrysin) inhibits activity of NF-κB. Tectochrysin (Techtochrysin) binds directly to the p50 unit. Tectochrysin (Techtochrysin) concentration-dependently inhibits the translocation of p50 and p65 into the nucleus through inhibition of the phosphorylation of IκB. To assess the inhibitory effect of Tectochrysin on cell growth of colon cancer cells (SW480, HCT116), cell viability is analyzed by MTT assay. The cells are treated with varying concentrations of Tectochrysin (Techtochrysin) (1, 5, 10 μg/mL) for 24 h. Tectochrysin (Techtochrysin) inhibits cell growth in colon cancer cells in a concentration-dependent manner. Tectochrysin (Techtochrysin) inhibits SW480 cells growth with IC 50 value of 6.3 μg/mL and HCT116 cells growth with IC 50 value of 8.4 μg/mL. Morphologic observation shows that the cells are reduced in size by the treatment of NSC 80687 (10 μg/mL) in SW480 cells and HCT116 cells. However, Tectochrysin (Techtochrysin) is not cytotoxic in the normal CCD-18co cells in the tested concentration by MTT assay. To delineate whether the induction of apoptotic cell death is critical for cell growth inhibition by NSC 80687, changes are evaluated in the chromatin morphology of cells using DAPI staining. To further characterize the apoptotic cell death by Tectochrysin (Techtochrysin), TUNEL staining assays are performed, and then the labeled cells are analyzed by fluorescence microscopy. Apoptotic cells number (DAPI-positive TUNEL stained cells) in SW480 cell is increased to 1 and 58 % by 0 and 10 μg/mL NSC 80687, respectively, and 1 and 54 % by 0 and 10 μg/mL Tectochrysin in HCT116. |
| 体内研究 | To elucidate the antitumor effects of Tectochrysin in in vivo, the tumor growth in colon cancer xenograft-bearing nude mice following Tectochrysin (NSC 80687) treatments is investigated. In HCT116 xenograft studies, Tectochrysin (NSC 80687) is administrated i.p. twice per week for 3 weeks to mice with tumors ranging from 200 to 300 mm 3 in volume. The mice are weighed twice per week. The changes in body weights between the control and the Tectochrysin (NSC 80687)-treated mice (n=10) are not remarkably different during the experiment. However, On day 21, the final tumor weights are recorded. Tumor weights and volumes in mice treated with Tectochrysin (NSC 80687) at 5 mg/kg doses are 57.9 % and 46.4 % of the vehicle group, respectively. |
| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 |
| 海关编号 | 29145090 |
| 上游原料 | 柯因二甲醚 |
| 参考资料 展开查看 | 1. [IF=11.413] Yanqiu Gu et al."Development of 3-mercaptopropyltrimethoxysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix."Acta Pharm Sin B. 2020 Oct;10:1856 |
520-28-5 - 简介
杨芽黄素是一种天然物质，属于类黄酮类化合物。它存在于许多植物中，尤其是在杨树的芽中含量较高。杨芽黄素具有以下特性和性质：性质：杨芽黄素为黄色的结晶性粉末，具有良好的溶解性，可溶于一些有机溶剂。它具有抗氧化、抗菌、抗炎等功效。
它可以提供保护细胞免受自由基损伤的抗氧化功能，对于调节免疫功能、抗衰老、保护皮肤等方面具有积极作用。
制法：通常可以通过从杨树芽中提取杨芽黄素来获得。提取先将杨树芽研磨成粉末状，然后使用适当的溶剂进行浸提，再采用过滤、浓缩和结晶等工艺步骤进行纯化得到杨芽黄素。
安全信息：杨芽黄素通常被认为是一种相对安全的物质，但不排除个别人可能存在过敏反应。对于孕妇、哺乳期妇女和有特殊过敏史的人群，应先咨询专业人士的意见。避免吸入和接触眼睛，如发生不适应立即停止使用。最后更新：2024-04-09 21:11:58
