CAY10444,英文名:(4R)-2-Undecyl-4-thiazolidinecarboxylic acid,CAS:298186-80-8,CAY10444 (BML-241) 是一种 sph
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最后更新：2024-01-02 23:10:35
298186-80-8
CAY10444((4R)-2-Undecyl-4-thiazolidinecarboxylic acid)
CAS: 298186-80-8
化学式: C15H29NO2S
| 中文名 | CAY10444 |
| 英文名 | (4R)-2-Undecyl-4-thiazolidinecarboxylic acid |
| 英文别名 | BML-241 CAY10444 CAY10444 Exclusive FNBSOIBCKUUVJJ-LSLKUGRBSA-N 2-UNDECYL-THIAZOLIDINE-4-CARBOXYLIC ACID 2-Undecylthiazolidine-4(R)-carboxylic acid (4R)-2-Undecyl-4-thiazolidinecarboxylic acid |
| CAS | 298186-80-8 |
| 化学式 | C15H29NO2S |
| 分子量 | 287.46 |
| 溶解度 | DMSO: >5 mg/mL |
| 存储条件 | 2-8°C |
| 外观 | 粉末 |
| 颜色 | white to off-white |
| 产品用途 | CAY10444 (BML-241) 是一种 sphingosine-1-phosphate 3 (S1P3) 拮抗剂。CAY10444 在表达 S1P3 受体的 HeLa 细胞中抑制 37% S1P 诱导的 Ca2+ 增加。 |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1: Tang HB, Jiang XJ, Wang C, Liu SC. S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. Biochem Biophys Res Commun. 2018 Mar 16. pii: S0006-291X(18)30543-6. doi: 10.1016/j.bbrc.2018.03.065. [Epub ahead of print] PubMed PMID: 29534963. 2: Shirakawa H, Katsumoto R, Iida S, Miyake T, Higuchi T, Nagashima T, Nagayasu K, Nakagawa T, Kaneko S. Sphingosine-1-phosphate induces Ca(2+) signaling and CXCL1 release via TRPC6 channel in astrocytes. Glia. 2017 Jun;65(6):1005-1016. doi: 10.1002/glia.23141. Epub 2017 Mar 16. PubMed PMID: 28300348. 3: Feuerborn R, Becker S, Potì F, Nagel P, Brodde M, Schmidt H, Christoffersen C, Ceglarek U, Burkhardt R, Nofer JR. High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. Atherosclerosis. 2017 Feb;257:29-37. doi: 10.1016/j.atherosclerosis.2016.12.009. Epub 2016 Dec 9. PubMed PMID: 28038379. 4: Tian T, Tian W, Yang F, Zhao R, Huang Q, Zhao Y. Sphingosine kinase 1 inhibition improves lipopolysaccharide/D-galactosamine-induced acute liver failure by inhibiting mitogen-activated protein kinases pathway. United European Gastroenterol J. 2016 Oct;4(5):677-685. Epub 2016 Mar 2. PubMed PMID: 27733910; PubMed Central PMCID: PMC5042311. 5: Tölle M, Klöckl L, Wiedon A, Zidek W, van der Giet M, Schuchardt M. Regulation of endothelial nitric oxide synthase activation in endothelial cells |
298186-80-8 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.479 ml | 17.394 ml | 34.787 ml |
| 5 mM | 0.696 ml | 3.479 ml | 6.957 ml |
| 10 mM | 0.348 ml | 1.739 ml | 3.479 ml |
| 5 mM | 0.07 ml | 0.348 ml | 0.696 ml |
