BW 245C,英文名:BW 245C,CAS:72814-32-5,化学式:C19H32N2O5,分子量:368.47,密度:1.167±0.06 g/cm3(Predicted),MSDS.
72814-32-5
BW 245C(BW 245C)
CAS: 72814-32-5
化学式: C19H32N2O5
| 中文名 | BW 245C |
| 英文名 | BW 245C |
| 别名 | 化合物 T14842 |
| 英文别名 | BW 245C 3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-(R*,S*)-(±)-4-imidazolineheptanioc acid (4S)-(3-[(3R,S)-3-CYCLOHEXYL-3-HYDROXYPROPYL]-2,5-DIOXO)-4-IMIDAZOLIDINE-HEPTANOIC ACID 4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R*,S*)-( -)- 4-Imidazolidineheptanoic acid, 3-[(3S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo-, (4R)-rel- 4-Imidazolidineheptanoic acid, 3-((3R)-3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (4S)-rel- |
| CAS | 72814-32-5 |
| 化学式 | C19H32N2O5 |
| 分子量 | 368.47 |
| 密度 | 1.167±0.06 g/cm3(Predicted) |
| 溶解度 | DMSO: 30mg/ml，可溶 |
| 酸度系数 | 4.77±0.10(Predicted) |
| 存储条件 | −20°C |
| 外观 | 固体 |
| 颜色 | off-white |
| 体外研究 | BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity. |
| 体内研究 | BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1 −/− mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1 −/− mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs. |
| WGK Germany | 3 |
72814-32-5 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.714 ml | 13.57 ml | 27.139 ml |
| 5 mM | 0.543 ml | 2.714 ml | 5.428 ml |
| 10 mM | 0.271 ml | 1.357 ml | 2.714 ml |
| 5 mM | 0.054 ml | 0.271 ml | 0.543 ml |
72814-32-5 - 简介
BW 245C 是一种化学物质，也被称为N-乙基-4-溴代苯胺(Bromoethylbenzene)。下面是关于 BW 245C的性质、用途、制法和安全信息的介绍：性质：
- 外观：BW 245C 是一种无色至浅黄色的液体。
- 溶解性：BW 245C 在有机溶剂中易溶解，但难溶于水。
用途：
- 它还可以用作溶剂，在有机合成中起到溶剂和中间体的作用。
制法：
- BW 245C 的制备方法通常是通过苯乙烯与溴或氯在酸催化剂存在下进行卤代反应得到。
安全信息：
- BW 245C 是一种有机化合物，具有一定的危险性。
- 它对眼睛、皮肤和呼吸系统有刺激性。
- 应避免直接接触皮肤、眼睛和服用。
- 使用时应戴上适当的防护措施，如穿戴防护服、戴上防护眼镜和呼吸器。
- 应在通风良好的地方操作，避免吸入其蒸气。
- 在使用和储存过程中应遵循正确的安全操作规程。最后更新：2024-04-09 02:00:13
