Indolicidin,英文名:Indolicidin,CAS:140896-21-5,化学式:C100H132N26O13,分子量:1906.28,水溶性:Soluble in water (1 m

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Indolicidin(Indolicidin)

CAS: 140896-21-5

化学式: C100H132N26O13

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中文名	Indolicidin
英文名	Indolicidin
别名	INDOLICIDIN肽 抗菌肽INDOLICIDIN
英文别名	IR-13-NH2 Indolicidin INDOLICIDIN ILPWKWPWWPWRR-NH2 IndolicidinIndolicid ILE-LEU-PRO-TRP-LYS-TRP-PRO-TRP-TRP-PRO-TRP-ARG-ARG-NH2 H-ILE-LEU-PRO-TRP-LYS-TRP-PRO-TRP-TRP-PRO-TRP-ARG-ARG-NH2 L-ArgininaMide,L-isoleucyl-L-leucyl-L-prolyl-L-tryptophyl-L-lysyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-tryptophyl-L-prolyl-L-tryptophyl-L-arginyl-
CAS	140896-21-5
化学式	C100H132N26O13
分子量	1906.28
水溶性	Soluble in water (1 mg/ml).
存储条件	−20°C
MDL号	MFCD00214306
体外研究	Indolicidin is comprised of 13 amino acids, 5 of which are tryptophan residues, and the carboxylterminal arginine is carboxamidated. Indolicidin has the highest tryptophan content of any known protein. The multiple tryptophan residues may play an important role in the function of this unique antibiotic peptide. Indolicidin is a tridecapeptide amide which possesses in vitro bactericidal activities comparable with the most active of the defensin or bactenecin peptides. Indolicidin binds purified surface lipopolysaccharide with high affinity and permeabilized the outer membrane of Escherichia coli to the small hydrophobic molecule 1-N-phenylnapthylamine (Mr 200), results consistent with indolicidin crossing the outer membrane via the self-promoted uptake pathway. The methyl esterification of indolicidin's carboxyl terminus increases its activity for Gram-negative and Gram-positive bacteria. In Gram-negative bacteria this is associated with an increased binding to lipopolysaccharide and increased permeabilization of the outer membrane. The cytoplasmic membrane is the site of action of indolicidin as assayed in Escherichia coli by the unmasking of cytoplasmic beta-galactosidase due to membrane permeabilization.
WGK Germany	3
RTECS	NM1890250
上游原料	FMOC-L-精氨酸 Fmoc-L-脯氨酸 Fmoc-L-亮氨酸 Fmoc-L-异亮氨酸

140896-21-5 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	0.525 ml	2.623 ml	5.246 ml
5 mM	0.105 ml	0.525 ml	1.049 ml
10 mM	0.052 ml	0.262 ml	0.525 ml
5 mM	0.01 ml	0.052 ml	0.105 ml

最后更新：2024-01-02 23:10:35