SDMA (Symmetric dimethylarginine),英文名:(2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentano

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30344-00-4 询问

SDMA (Symmetric dimethylarginine)((2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid)

CAS: 30344-00-4

化学式: C8H18N4O2

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中文名	SDMA (Symmetric dimethylarginine)
英文名	(2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid
别名	对称性二甲基精氨酸 N,N-二甲基精氨酸 对称N,N-二甲基精氨酸 对称N,N'-二甲基精氨酸溶液,100PPM (S)-2-氨基-5-((双(甲基氨基)亚甲基)氨基)戊酸 (2S)-2-氨基-5-[(N,N'-二甲基甲脒基)氨基]戊酸 NG,NG′-二甲基-L-精氨酸二(对羟基偶氮苯-P'-磺酸盐)盐
英文别名	SDMA-d6 Symmetric dimethylarginine NG,NG'-Dimethy-L-arginine-d6 L-Arg(Me, Me)-OH (syMMetrical) L-Arg(Me, Me)-OH (asyMMetrical) SDMA (Symmetric dimethylarginine) N5-[Bis(methylamino)methylene]-L-ornithine-d6 N5-[(Dimethylamino)iminomethyl]-L-ornithine-d6 (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid
CAS	30344-00-4
化学式	C8H18N4O2
分子量	202.25
密度	1.22±0.1 g/cm3(Predicted)
沸点	353.5±52.0 °C(Predicted)
酸度系数	2.48±0.24(Predicted)
存储条件	Keep in dark place,Inert atmosphere,Room temperature
稳定性	非常吸湿
外观	橙色粉末。
体外研究	SDMA is the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate. SDMA inhibits dose dependently the NO synthesis in intact endothelial cells, whereas it has no effect on protein expression of NOS. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α.
体内研究	SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR. Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction.
参考资料 展开查看	1. [IF=2.193] Yang Yang et al."Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method."J Anal Methods Chem. 2020;2020:4641709

30344-00-4 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	4.944 ml	24.721 ml	49.443 ml
5 mM	0.989 ml	4.944 ml	9.889 ml
10 mM	0.494 ml	2.472 ml	4.944 ml
5 mM	0.099 ml	0.494 ml	0.989 ml

最后更新：2024-01-02 23:10:35

30344-00-4 - 简介

SDMA (Symmetric dimethylarginine)是一种有机化合物，其结构与精氨酸类似，但具有两个甲基和一个胺基取代基。

性质：SDMA是无色晶体，可溶于水和有机溶剂。

用途：SDMA在临床上被广泛应用作为肾功能的生化指标。它是一种尿液中的代谢产物，可反映肾小球滤过率。SDMA被用来评估肾功能，并用于诊断和监测肾病、高血压和其他肾脏相关疾病。

制法：SDMA可以通过将精氨酸与甲酰氯（或甲酸甲酯）反应，然后通过结晶纯化获得。这种合成方法是通过在适当溶剂中将精氨酸与甲酰氯或甲酸甲酯反应来进行的。

安全信息：在正确使用的情况下，SDMA安全性较高。如任何化学物质一样，接触到高浓度的SDMA可能会对人体造成危害。在处理和使用SDMA时，必须采取适当的安全措施，包括佩戴化学防护手套和眼睛保护装置，并确保在通风良好的区域中操作。如有必要，应咨询专业人士或参考安全数据表以确保安全使用。最后更新：2024-04-09 20:48:19