SKF-86002,英文名:6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE,C

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SKF-86002(6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE)

CAS: 72873-74-6

化学式: C16H12FN3S

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中文名	SKF-86002
英文名	6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
别名	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
英文别名	SKF-86002 SKF 86002 DIHYDROCHLORIDE 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE 6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE
CAS	72873-74-6
化学式	C16H12FN3S
分子量	297.35
InChIKey	YOELZIQOLWZLQC-UHFFFAOYSA-N
密度	1.39±0.1 g/cm3(Predicted)
熔点	189-190°C(lit.)
沸点	476.1±55.0 °C(Predicted)
溶解度	DMSO: 9mg/ml，可溶
酸度系数	4.36±0.10(Predicted)
存储条件	Keep in dark place,Sealed in dry,2-8°C
外观	固体
颜色	off-white
体外研究	SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV). SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells. SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels. Western Blot Analysis Cell Line: U937 cells Concentration: 10 μM Incubation Time: 72 hours Result: Significantly reduced CD23 levels on IL-4-treated U937 cells.
体内研究	SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity. Animal Model: Lewis rats, with adjuvant-induced arthritis (AA) Dosage: 10 mg/kg, 30 mg/kg, 90 mg/kg Administration: Oral administration, daily, for 22 days Result: Significantly decreased hindleg volumes after injection of adjuvant.
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。
WGK Germany	3

72873-74-6 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.363 ml	16.815 ml	33.629 ml
5 mM	0.673 ml	3.363 ml	6.726 ml
10 mM	0.336 ml	1.681 ml	3.363 ml
5 mM	0.067 ml	0.336 ml	0.673 ml

最后更新：2024-01-02 23:10:35