JNJ-10198409,英文名:N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine,CAS:62751
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最后更新：2024-01-02 23:10:35
627518-40-5
JNJ-10198409(N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine)
CAS: 627518-40-5
化学式: C18H16FN3O2
| 中文名 | JNJ-10198409 |
| 英文名 | N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine |
| 别名 | 化合物JNJ-?10198409 3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基)苯基胺 |
| 英文别名 | JNJ-10198409 JNJ-10198409, Free Base PDGFR Tyrosine Kinase Inhibitor IV JNJ-10198409 (This product is only available in Japan.) N-(3-Fluorophenyl)-6,7-dimethoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-amine N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy-indeno[1,2-c]pyrazol-3-amine 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine Indeno[1,2-c]pyrazol-3-amine, N-(3-fluorophenyl)-1,4-dihydro-6,7-dimethoxy- RWJ 540973, 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, N-(3-fluorophenyl)-2,4-dihydro-6,7-dimethoxy-Indeno[1,2-c]pyrazol-3-amine |
| CAS | 627518-40-5 |
| 化学式 | C18H16FN3O2 |
| 分子量 | 325.34 |
| 密度 | 1.366±0.06 g/cm3(Predicted) |
| 熔点 | 171-173.5 °C |
| 沸点 | 528.8±50.0 °C(Predicted) |
| 溶解度 | DMSO: >10 mg/mL |
| 酸度系数 | 14.01±0.20(Predicted) |
| 存储条件 | −20°C |
| 外观 | 固体 |
| 颜色 | off-white |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1: Das F, Ghosh-Choudhury N, Venkatesan B, Kasinath BS, Ghosh Choudhury G. PDGF receptor-β uses Akt/mTORC1 signaling node to promote high glucose-induced renal proximal tubular cell collagen I (α2) expression. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F291-F307. doi: 10.1152/ajprenal.00666.2016. Epub 2017 Apr 19. PubMed PMID: 28424212; PubMed Central PMCID: PMC5582895. 2: Danovi D, Folarin A, Gogolok S, Ender C, Elbatsh AM, Engström PG, Stricker SH, Gagrica S, Georgian A, Yu D, U KP, Harvey KJ, Ferretti P, Paddison PJ, Preston JE, Abbott NJ, Bertone P, Smith A, Pollard SM. A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1. PLoS One. 2013 Oct 30;8(10):e77053. doi: 10.1371/journal.pone.0077053. eCollection 2013. PubMed PMID: 24204733; PubMed Central PMCID: PMC3813721. 3: Hiram-Bab S, Katz LS, Shapira H, Sandbank J, Gershengorn MC, Oron Y. Platelet-derived growth factor BB mimics serum-induced dispersal of pancreatic epithelial cell clusters. J Cell Physiol. 2014 Jun;229(6):743-51. doi: 10.1002/jcp.24493. PubMed PMID: 24129818. |
627518-40-5 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.074 ml | 15.369 ml | 30.737 ml |
| 5 mM | 0.615 ml | 3.074 ml | 6.147 ml |
| 10 mM | 0.307 ml | 1.537 ml | 3.074 ml |
| 5 mM | 0.061 ml | 0.307 ml | 0.615 ml |
