盐酸氯胍,英文名:proguanil hydrochloride,CAS:637-32-1,化学式:C11H17Cl2N5,分子量:290.19,熔点:249-2510C,沸点:402.7°C at
637-32-1
盐酸氯胍(proguanil hydrochloride)
CAS: 637-32-1
化学式: C11H17Cl2N5
| 中文名 | 盐酸氯胍 |
| 英文名 | proguanil hydrochloride |
| 别名 | 盐酸丙胍 盐酸氯胍 吉非罗齐杂质A 盐酸氯胍 标准品 盐酸氯胍 USP标准品 N1-(4-氯苯基)-N5-异丙基双胍盐酸盐 |
| 英文别名 | 3359rp diguanyl Proguanil HCL proguanil hydrochloride chlorguanidehydrochloride chloroguanidehydrochloride Chloroguanide hydrochloride chloroguanidinehydrochloride 1-(p-chlorophenyl)-5-isopropylbiguanidehydrochloride N1-(4-Chlorophenyl)-N5-isopropylbiguanide Hydrochloride 1-(p-chlorophenyl)-5-isopropyl-biguanidmonohydrochloride 1-{(1E)-amino[(4-chlorophenyl)amino]methylidene}-2-(1-methylethyl)guanidine hydrochloride |
| CAS | 637-32-1 |
| EINECS | 211-283-7 |
| 化学式 | C11H17Cl2N5 |
| 分子量 | 290.19 |
| InChI | InChI=1/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H |
| 熔点 | 249-2510C |
| 沸点 | 402.7°C at 760 mmHg |
| 闪点 | 197.4°C |
| 蒸汽压 | 1.07E-06mmHg at 25°C |
| 溶解度 | 乙腈: 水: ~ 1mg/ml (60/40) |
| 存储条件 | 2-8°C |
| 外观 | 固体 |
| 体外研究 | Proguanil per se has only weak antimalarial activity in vitro (IC 50 =2.4-19 μM), and its effectiveness depends on the active metabolite Cycloguanil (IC 50 =0.5-2.5 nM). The Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor. The combination of Atovaquone and Proguanil is synergistic in vitro . Both drugs also have activity against gametocytes and pre-erythrocytic (hepatic) stages of malaria parasites. Proguanil acts as a biguanide rather than as its metabolite Cycloguanil (a parasite dihydrofolate reductase [DHFR] inhibitor) to enhance the Atovaquone effect. Proguanil-mediated enhancement is specific for Atovaquone, since the effects of other mitochondrial electron transport inhibitors, such as Myxothiazole and Antimycin, are not altered by inclusion of Proguanil. 5-HT 3 receptor responses are reversibly inhibited by Proguanil, the metabolite 4-chlorophenyl-1-biguanide (CPB) and the active metabolite Cycloguanil (CG), with an IC 50 of 1.81, 1.48 and 4.36 μM, respectively. |
| 体内研究 | Proguanil (p.o.; 2.9 mg/kg body weight; daily for 5 days and 6 weeks respectively) shows mild degenerative changes for five days, while shows severe degenerative changes for six weeks in wistar strain albino rats. Serum testosterone level is significantly decreased for proguanil treatment rats. Administration of Malarone (Atovaquone and Proguanil) to experimentally B. gibsoni infected two dogs in chronic stage and three dogs in acute stage results in decrease in parasitemia, and clinical improvements are observed. |
| 危险品标志 | T - 有毒物品 |
| 风险术语 | 25 - 吞食有毒。 |
| 安全术语 | 45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 |
| 危险品运输编号 | 3249 |
| WGK Germany | 3 |
| RTECS | DU1750000 |
| 海关编号 | 2925294500 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
637-32-1 - 简介
盐酸氯胍是一种无机化合物。下面是关于盐酸氯胍的性质、用途、制法和安全信息的介绍：性质：
1. 盐酸氯胍是易溶于水的固体，其溶液呈酸性。
2. 它是一种具有强腐蚀性的化合物，可以破坏有机物的结构。
3. 盐酸氯胍具有氧化性和杀菌性能。
用途：
1. 盐酸氯胍主要用作消毒剂和杀菌剂，可以用于水处理和消毒清洁剂的制备。
2. 它也可用于纺织品和皮革工业的漂白剂，以及造纸工业的漂白和杀菌剂。
制法：
1. 盐酸氯胍可以通过将氯胍溶解在盐酸溶液中制备而成。
2. 具体步骤为，在适当的条件下，将氯胍粉末与盐酸溶液反应，结晶得到盐酸氯胍。
安全信息：
1. 盐酸氯胍具有刺激性气味，在操作和使用时需要采取适当的防护措施，如佩戴手套、护目镜和防护服，保持通风良好。
2. 避免与皮肤和眼睛接触，如果接触到盐酸氯胍，应立即用大量清水冲洗。
3. 将盐酸氯胍保存在干燥、通风良好的地方，远离火源和可燃物。
4. 在处理盐酸氯胍废弃物时注意环境保护要求，并遵守当地法规。最后更新：2024-04-10 22:29:15
