YM-46303,英文名:YM-46303,CAS:171722-81-9,化学式:C20H23ClN2O2,分子量:358.87,MSDS.

171722-81-9 询问

YM-46303(YM-46303)

CAS: 171722-81-9

化学式: C20H23ClN2O2

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中文名	YM-46303
英文名	YM-46303
别名	化合物 T13370
英文别名	YM-46303 171722-81-9
CAS	171722-81-9
化学式	C20H23ClN2O2
分子量	358.87
存储条件	2-8℃
体内研究	YM-46303 shows approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, and about 5-fold greater selectivity for urinary bladder contraction against salivary secretion in rats compared to oxybutynin. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects. YM-46303 shows in vivo selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration.