牛磺胆酸,英文名:Taurocholic Acid,CAS:81-24-3,化学式:C26H45NO7S,分子量:515.7,密度:1.0902 (rough estimate),熔点:125°C (
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牛磺胆酸是一种无色结晶性固体，具有独特的苦味。它在常温下可溶于水，并可形成无色或微黄色的溶液。
牛磺胆酸是胆汁的主要成分之一，在胆汁中起着重要的消化和吸收脂肪的作用。它通过乳化作用，将脂肪分子细分为小颗粒，增大了脂肪的表面积，便于胰脂酶的作用和脂肪的消化吸收。
牛磺胆酸还具有助于脂溶性维生素（如维生素A、维生素D、维生素E和维生素K）的吸收和代谢。它也是胆固醇代谢的重要组成部分，通过与胆固醇结合形成胆酸-胆固醇酯，促进胆固醇的排泄。
最后更新：2024-04-10 22:29:15
81-24-3
牛磺胆酸(Taurocholic Acid)
CAS: 81-24-3
化学式: C26H45NO7S
| 中文名 | 牛磺胆酸 |
| 英文名 | Taurocholic Acid |
| 别名 | 牛膽酸 牛黄胆酸 牛磺胆酸 胺乙磺膽酸 牛磺胆酸-2,2,4,4-D4酸 N-(3α,7α,12α)三羟基-5β-胆甾烷-24-酰基牛黄酸 3α,7α,12α-三羟基-5β-胆甾烷-24-羧酸-24-牛黄酸酰胺 N-(3ALPHA,7ALPHA,12ALPHA)三羟基-5Β-胆甾烷-24-酰基牛黄酸 |
| 英文别名 | taurocholate Taurocholic Acid n-choloyltaurine 3,7,12-Trihydroxy-5-cholan-24-oicacid24-taurineamide 5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL N-(2-SULPHOETHYL)-AMIDE 2-((3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholan-24-yl)amino)ethan 2-[[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]ethanesulphonic acid |
| CAS | 81-24-3 |
| EINECS | 201-336-2 |
| 化学式 | C26H45NO7S |
| 分子量 | 515.7 |
| 密度 | 1.0902 (rough estimate) |
| 熔点 | 125°C (rough estimate) |
| 比旋光度 | D18 +38.8° (c = 2 in alcohol) |
| 溶解度 | 易溶于水，溶于乙醇，几乎不溶于乙醚、乙酸乙酯。遇酸碱分解成胆酸和牛磺酸 |
| 折射率 | 1.5650 (estimate) |
| 酸度系数 | 1.4(at 25℃) |
| 存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 稳定性 | 吸湿性 |
| 敏感性 | Hygroscopic |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 物化性质 | 化学性质 非结晶形粉末。 熔点125℃（分解），[α]20/D+38.8°（乙醇-水）。易吸湿。易溶于水，溶于乙醇，几乎不溶于乙醚、乙酸乙酯。遇酸碱分解成胆酸和牛磺酸。 |
| MDL号 | MFCD00053458 |
| 下游产品 | 去氢胆酸 |
| 参考资料 展开查看 | 1. 曹妍,李婷,常安琪,蒋珍珍,于娟,屠鹏飞,宋月林.蛇胆中胆汁酸类化学成分分析[J].中国中药杂志,2021,46(01):130-138. 2. Zhang, Xiaoyong, et al. "Comparative metabolomics analysis of cervicitis in human patients and a phenol mucilage-induced rat model using liquid chromatography tandem mass spectrometry." Frontiers in pharmacology 9 (2018): 282.https://doi.org/10.3389/fphar. 3. [IF=5.81] Zhang Xiaoyong et al."Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry."Front Pharmacol. 2018 Apr;0:282 4. [IF=3.935] Ziying Liu et al."Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma."J Pharmaceut Bio 5. [IF=3.361] Qingqing Song et al."Polarity-extended quantitative analysis of bear bile and its analogues using serially coupled reversed phase-hydrophilic interaction liquid chromatography-tailored multiple reaction monitoring."Rsc Adv. 2017 Nov;7(83):52822-52831 6. [IF=5.878] Min Wen et al."Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis."Phytother Res. 2021 Jul;35(7):3799-3811 7. [IF=5.34] Kaihui Zhang et al."A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis."Phytomedicine. 2021 Oct;91:153683 8. [IF=3.935] Song Lin et al."A systemic combined nontargeted and targeted LC-MS based metabolomic strategy of plasma and liver on pathology exploration of alpha-naphthylisothiocyanate induced cholestatic liver injury in mice."J Pharmaceut Biomed. 2019 Jul;171:180 9. [IF=3.935] Runjing Zhang et al."Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics."J Pharmaceut Biomed. 2020 Feb;179:112966 10. [IF=5.396] Juan Wu et al."Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes."Food Funct. 2022 Feb;: 11. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885 |
81-24-3 - 性质
牛磺胆酸，也称为犬磺胆酸或牛磺甲酸，是一种天然存在于动物体内的有机化合物。它属于胆酸类化合物，具有多种重要的生物学功能。牛磺胆酸是一种无色结晶性固体，具有独特的苦味。它在常温下可溶于水，并可形成无色或微黄色的溶液。
牛磺胆酸是胆汁的主要成分之一，在胆汁中起着重要的消化和吸收脂肪的作用。它通过乳化作用，将脂肪分子细分为小颗粒，增大了脂肪的表面积，便于胰脂酶的作用和脂肪的消化吸收。
牛磺胆酸还具有助于脂溶性维生素（如维生素A、维生素D、维生素E和维生素K）的吸收和代谢。它也是胆固醇代谢的重要组成部分，通过与胆固醇结合形成胆酸-胆固醇酯，促进胆固醇的排泄。
最后更新：2024-04-10 22:29:15
