Affect the extraction of traditional Chinese medicine in the processing of incoming materials
People who do processing with incoming materials are often troubled by a problem: yield. When you get the materials in the factory, why do the yields often vary? The following national standard product network is combined with actual production to talk about the impactTraditional Chinese Medicine ExtractionCommon factors for yield:
The key to solvent extraction lies in selecting the appropriate solvent and extraction method, but during the operation, factors such as the particle size of the raw material, extraction time, extraction temperature, and equipment conditions can also affect the extraction efficiency, which must be taken into account.
1. The particle size crushing of raw materials is a necessary link in the pretreatment process of traditional Chinese medicine. By crushing, the surface area of the drug can be increased, the dissolution and absorption of the drug can be promoted, and the leaching of the active ingredients in the medicinal materials can be accelerated. However, if the crushing is too fine, the specific surface area of the medicinal powder is too large, and the adsorption effect is enhanced, which will affect the diffusion speed. Especially for traditional Chinese medicines containing more protein and polysaccharides, if the crushing is too fine, it is easy to produce a sticky phenomenon when extracting with water, which will affect the extraction efficiency. The crushing degree of raw materials should consider the extraction solvent and medicinal parts selected. If it is extracted with water, it is best to use coarse powder, and it can be extracted with organic solvents. The raw materials are rhizomes In practice, some friends called our Zhongguan Health Association to ask if our medicinal materials could be powdered and sent for extraction. Through this factor, I don't think we need to explain too much.
2. Extraction temperature. For most materials with mature processes, the extraction temperature has strict instructions, and we will do it according to customer requirements. However, there are still quite a few traditional Chinese medicine prescriptions that want to be improved, but there is no process, so the difference in extraction temperature also results in different yields. The increase in temperature accelerates the movement of molecules, and the speed of penetration, diffusion and dissolution is also accelerated, so the extraction efficiency of hot extraction is higher than that of cold extraction, but the removal of impurities also increases accordingly. In addition, the temperature cannot be increased indefinitely. Excessive temperature will cause some active ingredients to be damaged and oxidized and decomposed. Generally, heating to about 60 ° C is appropriate, and the maximum should not exceed 100 ° C.
3. Time of extraction
existmedicinal materialsBefore the concentration of active ingredients inside and outside the cell reaches equilibrium, the amount of extraction increases as the extraction time increases. The extraction time does not need to be extended indefinitely, as long as it is suitable, the extraction is complete. Generally speaking, heat extraction is 3 times, 2 hours each time (for most materials).
In view of the above 3 points, which are also the most important 3 points in the processing process, different manufacturers have different extraction prices, which is basically the degree of the above 3 points. How much material is added? Extraction temperature control, extraction time and frequency all determine the final yield of your material, so friends can't just look at the extraction price, but also whether the extraction quality is qualified.
