6,4''-DIHYDROXYAURONE,英文名:6,4''-DIHYDROXYAURONE,CAS:5786-54-9,化学式:C15H10O4,分子量:2
5786-54-9
6,4''-DIHYDROXYAURONE(6,4''-DIHYDROXYAURONE)
CAS: 5786-54-9
化学式: C15H10O4
<"" ="xl" "">| 中文名 | 6,4''-DIHYDROXYAURONE |
| 英文名 | 6,4''-DIHYDROXYAURONE |
| 别名 | 化合物HISPIDOL |
| 英文别名 | NSC356828 (Z)-Hispidol 6,4''-DIHYDROXYAURONE 3(2H)-Benzofuranone, 6-hydroxy-2-[(4-hydroxyphenyl)methylene]-, (2Z)- |
| CAS | 5786-54-9 |
| 化学式 | C15H10O4 |
| 分子量 | 254.24 |
| 密度 | 1.489±0.06 g/cm3(Predicted) |
| 熔点 | 286-288 °C |
| 沸点 | 523.8±50.0 °C(Predicted) |
| 酸度系数 | 7.59±0.20(Predicted) |
| 存储条件 | 2-8℃ |
| 体外研究 | Hispidol shows potent inhibitory effect (>70%) on the TNF-α-induced adhesion of monocytes to colon epithelial cells, which is one of the hallmark events leading to inflammatory bowel disease (IBD). Hispidol shows strong inhibitory activities against TNF-α-induced monocytic-colonic epithelial cell adhesion as well as LPS-induced TNF-α expression, is as an excellent candidate for IBD drug development. This inhibition of TNF-α expression by hispidol corresponds to the additional inhibitory activity against AP-1 transcriptional activity, which is another transcription factor required for high level TNF-α expression. |
| 体内研究 | The oral administration of hispidol suppresses significantly and dose-dependently TNBS-induced rat colitis. Oral administration of hispidol suppresses TNBS-induced colitis in a dose-dependent manner. There is a significant recovery in body weight decrease and colon tissue edematous inflammation. A higher dose (30 mg/kg) of hispidol shows a similar recovery effect to that of 300 mg/kg sulfasalazine. In the colon tissues, TNBS induces a dramatic increase in the level of MPO, a biochemical marker of inflammation, which is suppressed significantly by hispidol in a dose-dependent manner. |
5786-54-9 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.693 ml | 18.467 ml | 36.933 ml |
| 5 mM | 0.739 ml | 3.693 ml | 7.387 ml |
| 10 mM | 0.369 ml | 1.847 ml | 3.693 ml |
| 5 mM | 0.074 ml | 0.369 ml | 0.739 ml |
5786-54-9 - 简介
6,4''-二羟基氧杂络黄的性质是其化学名称为2,3,9,10-四甲氧基-6,4''-二羟基氧杂络黄。它是一种黄色结晶固体，可溶于有机溶剂如乙醇和二氯甲烷，不溶于水。6,4''-二羟基氧杂络黄的主要用途是作为有机染料和颜料。它在染料工业中用于染料配方、纺织、塑料和涂料中的颜色加品。它也被广泛应用于生物化学和医学领域，作为染色剂或指示剂。它还可以用于某些光敏化学反应以及金属螯合等化学实验和研究中。
制备6,4''-二羟基氧杂络黄的方法有多种。一种常用的方法是通过将2,3,9,10-四甲氧基-5,7-二羟基二芳基托叔丁基对苯酚与醋酸钠进行缩合反应，并经过后续的氧化、醋酸化和硝化等步骤得到产物。
安全信息：6,4''-二羟基氧杂络黄在化学结构中存在羟基和氧杂支链，它可能对环境和人体产生一定程度的危害。在使用和处理时应注意遵守相关的安全操作规程。应避免吸入粉尘或溶液，并避免直接接触皮肤和眼睛。在使用和贮存时应放置于干燥、阴凉和通风良好的地方，远离火源和易燃物品。如意外接触或吸入，应立即进行清洗和适当的医疗处理。最后更新：2024-04-09 21:11:58
