GW806742X,英文名:GW806742X,CAS:579515-63-2,化学式:C25H22F3N7O4S,分子量:573.55,密度:1.524±0.06 g/cm3(Predicted),

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579515-63-2 询问

GW806742X(GW806742X)

CAS: 579515-63-2

化学式: C25H22F3N7O4S

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中文名	GW806742X
英文名	GW806742X
别名	化合物GW806742X 3-((4-(甲基(4-(3-(4-(三氟甲氧基)苯基)脲基)苯基)氨基)嘧啶-2-基)氨基)苯磺酰胺
英文别名	CS-2659 GW806742X GW-806742X GW 806742X 1-[4-[methyl-[2-(3-sulfamoylanilino)pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethoxy)phenyl]urea 3-((4-(Methyl(4-(3-(4-(trifluoromethoxy)phenyl)ureido)phenyl)amino)pyrimidin-2-yl)amino)benzenesulfonamide Benzenesulfonamide, 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-
CAS	579515-63-2
化学式	C25H22F3N7O4S
分子量	573.55
密度	1.524±0.06 g/cm3(Predicted)
溶解度	DMSO : ≥ 125 mg/mL (217.94 mM)
酸度系数	10.09±0.60(Predicted)
存储条件	-20℃
体外研究	GW806742X (0.1-10000 nM) inhibits necroptotic death of wild-type mouse dermal fibroblasts (MDFs) stimulated with TSQ (1 ng/mL TNF, 500 nM compound A (Smac mimetic), 10 μM Q-VD-OPh) in a dose-dependent manner.GW806742X shows inhibition of VEGF induced proliferation of HUVECs with an IC50 of 5 nM.
参考资料 展开查看	1: Moreira-Nunes CA, Mesquita FP, Portilho AJS, Mello Júnior FAR, Maués JHDS, Pantoja LDC, Wanderley AV, Khayat AS, Zuercher WJ, Montenegro RC, de Moraes- Filho MO, de Moraes MEA. Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia. Sci Rep. 2020 Dec 4;10(1):21272. doi: 10.1038/s41598-020-78024-8. PMID: 33277547; PMCID: PMC7718893. 2: Shlomovitz I, Erlich Z, Speir M, Zargarian S, Baram N, Engler M, Edry-Botzer L, Munitz A, Croker BA, Gerlic M. Necroptosis directly induces the release of full-length biologically active IL-33 in vitro and in an inflammatory disease model. FEBS J. 2019 Feb;286(3):507-522. doi: 10.1111/febs.14738. Epub 2019 Jan 4. PMID: 30576068. 3: Lusthaus M, Mazkereth N, Donin N, Fishelson Z. Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity. Front Immunol. 2018 Feb 23;9:306. doi: 10.3389/fimmu.2018.00306. PMID: 29527209; PMCID: PMC5829068. 4: González-Juarbe N, Gilley RP, Hinojosa CA, Bradley KM, Kamei A, Gao G, Dube PH, Bergman MA, Orihuela CJ. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015 Dec 11;11(12):e1005337. doi: 10.1371/journal.ppat.1005337. PMID: 26659062; PMCID: PMC4676650.

579515-63-2 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.744 ml	8.718 ml	17.435 ml
5 mM	0.349 ml	1.744 ml	3.487 ml
10 mM	0.174 ml	0.872 ml	1.744 ml
5 mM	0.035 ml	0.174 ml	0.349 ml

最后更新：2024-01-02 23:10:35