Hydroxocobalamin monohydrochloride,英文名:Hydroxocobalamin monohydrochloride,CAS:59461-30-2,化学式:C62H89C

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Hydroxocobalamin monohydrochloride(Hydroxocobalamin monohydrochloride)

CAS: 59461-30-2

化学式: C62H89ClCoN13O15P

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中文名	Hydroxocobalamin monohydrochloride
英文名	Hydroxocobalamin monohydrochloride
别名	羟钴胺单盐酸盐 维生素 B12A 化合物 T13731
英文别名	Einecs 261-772-4 Vitamin B12a monohydrochloride hydroxocobalamin monohydrochloride Hydroxocobalamin monohydrochloride Cobinamide hydroxide dihydrogen phosphate (ester), inner salt 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosyl-1H-benzimidazole monohydrochloride Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3), monohydrochloride
CAS	59461-30-2
EINECS	261-772-4
化学式	C62H89ClCoN13O15P
分子量	1381.83
溶解度	甲醇: 在20 °C时溶解10mg/mL，澄清，深红色
存储条件	2-8°C
外观	整洁
体外研究	The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide and hydroxocobalamin attenuates vascular responses to NO in vitro .
体内研究	Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI. Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin). More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.
WGK Germany	3