Bay 65-1942 hydrochloride,英文名:7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piper

600734-06-3 询问

Bay 65-1942 hydrochloride(7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride)

CAS: 600734-06-3

化学式: C22H25N3O4.ClH

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中文名	Bay 65-1942 hydrochloride
英文名	7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
别名	化合物 T14508 7-[2-(环丙基甲氧基)-6-羟基苯基]-1,4-二氢-5-[(3S)-3-哌啶基]-2H-吡啶并[2,3-D][1,3]恶嗪盐酸盐
英文别名	Bay 65-1942 HCl KINK-1 hydrochloride Bay 65-1942 (HCl salt) Bay 65-1942 hydrochloride Bay 65-1942 (hydrochloride) (S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
CAS	600734-06-3
化学式	C22H25N3O4.ClH
分子量	431.917
存储条件	-20°C
外观	粉末
颜色	white to beige
体外研究	Delivery of Bay 65-1942 prior to ischemia significantly decreases left ventricular infarct size compared with animals receiving vehicle. Compared with sham animals, animals receiving vehicle have a significant increase in the infarct-to-area at risk (AAR) ratio (70.7±3.4 vs. 5.8±3.4%, P<0.05). This ratio is significantly reduced by treatment with Bay 65-1942 at each time point (prior to ischemia 42.7±4.1%, at reperfusion 42.7±7.5%, 2 h of reperfusion 29.4±5.2%; each group P<0.05 vs. vehicle). Animals pretreated with Bay 65-1942 (n=3) have significantly attenuated CK-MB levels compared with those animals without treatment prior to IR (14,170 ±3,219 units, P<0.05 vs. vehicle).
体内研究	Inhibitors of MEK (AZD6244) and IKK (BAY 65-1942) are used at their IC 50 concentrations, as determined by a 48 hour MTS assay, which achieve sufficient inhibition of kinase activity. MYL-R cells are treated for 24 hours with AZD6244 (5 µM), BAY 65-1942 (10 µM), or a combination of these inhibitors at the same concentrations. AZD6244 and BAY 65-1942 demonstrate synergistic inhibition of cell viability at the dose combination (5 µM AZD6244+10 µM BAY 65-1942), which correlates with IC 75 (CI = 0.48±0.01). Synergism is also indicated at the IC 50 (CI = 0.56±0.09) and IC 90 (CI = 0.46±0.02) dose combinations reported by the software (CI values are the mean of three independent experiments, ± standard deviation). AZD6244 and BAY 65-1942 treatment induces 2- and 1.3-fold caspase 3/7 activation, respectively, compared to the DMSO-treated cells. Treatment with a combination of AZD6244 plus BAY 65-1942 leads to a 3.2-fold increase in caspase 3/7 activity.

600734-06-3 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.315 ml	11.576 ml	23.153 ml
5 mM	0.463 ml	2.315 ml	4.631 ml
10 mM	0.232 ml	1.158 ml	2.315 ml
5 mM	0.046 ml	0.232 ml	0.463 ml

最后更新：2024-01-02 23:10:35