SB742457,英文名:SB742457,CAS:607742-69-8,化学式:C19H19N3O2S,分子量:353.44,密度:1.292,沸点:608.3±45.0 °C(Predicted

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607742-69-8 询问

SB742457(SB742457)

CAS: 607742-69-8

化学式: C19H19N3O2S

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中文名	SB742457
英文名	SB742457
别名	化合物SB 742457 化合物GW791343 (HCL) 3-苯磺酰基-8-(哌嗪-1-基)喹啉 3-苯基磺酰基-8-(哌嗪-1-基)喹啉
英文别名	SB742457 Sb-742457 Sb 742457 Gsk 742457 Intepirdine(SB742457) 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-
CAS	607742-69-8
化学式	C19H19N3O2S
分子量	353.44
密度	1.292
沸点	608.3±45.0 °C(Predicted)
溶解度	溶于DMSO，不溶于水
酸度系数	8?+-.0.10(Predicted)
存储条件	-20℃
体外研究	SB-742457是一种选择性的5-HT6受体拮抗剂，具有认知，记忆和增强学习的效果。SB-742457是一种新型的认知增强剂，用于治疗阿尔茨海默氏病。SB-742457是一种潜在的药剂，可增强Donepezil治疗轻度至中度阿尔茨海默氏病的稳定性。
体内研究	SB-742457是一种有效的，选择性5-HT6受体拮抗剂，在新物体识别测试中，可逆转Scopolamine诱导的学习缺陷，在老年大鼠水迷宫任务中，可提高学习性能。
参考资料 展开查看	1. Callaghan CK, Hok V, Della-Chiesa A, et al. Age-related declines in delayed non-match-to-sample performance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology. 2012 Oct;63(5):890-7.2. Codony X, Vela JM, Ramírez MJ. 5-HT(6) receptor and cognition. Curr Opin Pharmacol. 2011 Feb;11(1):94-100.3. Maher-Edwards G, Dixon R, Hunter J, et al. SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study. Int J Geriatr Psychiatry. 2011 May;26(5):536-44.4. Maher-Edwards G, Zvartau-Hind M, Hunter AJ, et al. Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease. Curr Alzheimer Res. 2010 Aug;7(5):374-85.

607742-69-8 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.829 ml	14.147 ml	28.293 ml
5 mM	0.566 ml	2.829 ml	5.659 ml
10 mM	0.283 ml	1.415 ml	2.829 ml
5 mM	0.057 ml	0.283 ml	0.566 ml

最后更新：2024-01-02 23:10:35