PKR-IN-C16,英文名:PKR-IN-C16,CAS:608512-97-6,化学式:C13H8N4OS,分子量:268.29,密度:1.604±0.06 g/cm3(Predicted),沸点

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608512-97-6 询问

PKR-IN-C16(PKR-IN-C16)

CAS: 608512-97-6

化学式: C13H8N4OS

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中文名	PKR-IN-C16
英文名	PKR-IN-C16
别名	化合物PKR-IN-C16 咪唑氧吲哚 PKR 抑制剂 8-((1H-咪唑-4-基)亚甲基)-6,8-二氢-7H-噻唑并[5,4-E]吲哚-7-酮
英文别名	GW 506033X PKR-IN-C16 PKR INHIBITOR InSolution? PKR Inhibitor Imidazolo-oxindole PKR inhibitor C16 8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE (Z)-8-((1H-Imidazol-4-yl)methylene)-6H-thiazolo[5,4-e]indol-7(8H)-one 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
CAS	608512-97-6
化学式	C13H8N4OS
分子量	268.29
密度	1.604±0.06 g/cm3(Predicted)
沸点	674.6±55.0 °C(Predicted)
溶解度	DMSO: 溶解12mg/mL
酸度系数	10.20±0.20(Predicted)
存储条件	-20°C
稳定性	自购买之日起2年内稳定供应。DMSO中的溶液可以在-20 ° 下储存长达1个月。
外观	橙色至橙棕色固体
颜色	yellow to orange-brown
危险品标志	Xi - 刺激性物品
风险术语	36/37/38 - 刺激眼睛、呼吸系统和皮肤。
安全术语	26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
WGK Germany	3
参考资料 展开查看	1: Naz F, Shahbaaz M, Khan S, Bisetty K, Islam A, Ahmad F, Hassan MI. PKR-inhibitor binds efficiently with human microtubule affinity-regulating kinase 4. J Mol Graph Model. 2015 Nov;62:245-52. doi: 10.1016/j.jmgm.2015.10.009. PubMed PMID: 26519933. 2: Tronel C, Page G, Bodard S, Chalon S, Antier D. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83. doi: 10.1016/j.neuint.2013.10.012. PubMed PMID: 24211709. 3: Clerzius G, Shaw E, Daher A, Burugu S, Gélinas JF, Ear T, Sinck L, Routy JP, Mouland AJ, Patel RC, Gatignol A. The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication. Retrovirology. 2013 Sep 11;10:96. doi: 10.1186/1742-4690-10-96. PubMed PMID: 24020926; PubMed Central PMCID: PMC3848765. 4: Bilgin DD, Liu Y, Schiff M, Dinesh-Kumar SP. P58(IPK), a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis. Dev Cell. 2003 May;4(5):651-61. PubMed PMID: 12737801. 5: Gerotto M, Dal Pero F, Pontisso P, Noventa F, Gatta A, Alberti A. Two PKR inhibitor HCV proteins correlate with early but not sustained response to interferon. Gastroenterology. 2000 Dec;119(6):1649-55. PubMed PMID: 11113086.

608512-97-6 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	3.727 ml	18.637 ml	37.273 ml
5 mM	0.745 ml	3.727 ml	7.455 ml
10 mM	0.373 ml	1.864 ml	3.727 ml
5 mM	0.075 ml	0.373 ml	0.745 ml

最后更新：2024-01-02 23:10:35