CCG-63802,英文名:CCG-63802,CAS:620112-78-9,化学式:C26H18N4O2S,分子量:450.51,密度:1.31,沸点:547.9±60.0 °C(Predicte

620112-78-9 询问

CCG-63802(CCG-63802)

CAS: 620112-78-9

化学式: C26H18N4O2S

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中文名	CCG-63802
英文名	CCG-63802
别名	化合物 T14897 RGS抑制剂(CCG-63802) ALPHA-[[9-甲基-2-(3-甲基苯氧基)-4-氧代-4H-吡啶并[1,2-A]嘧啶-3-基]亚甲基]-2-苯并噻唑乙腈
英文别名	CCG63802 CCG-63802 CCG 63802 (E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)a (E)-2-(Benzo[d]thiazol-2-yl)-3-(9-methyl-4-oxo-2-(m-tolyloxy)-4H-pyrido[1,2-a]pyrimidin-3-yl)acry α-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile 2-Benzothiazoleacetonitrile, α-[[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]- alpha-[[9-Methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]methylene]-2-benzothiazoleacetonitrile (2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile
CAS	620112-78-9
化学式	C26H18N4O2S
分子量	450.51
密度	1.31
沸点	547.9±60.0 °C(Predicted)
酸度系数	-0.42±0.70(Predicted)
存储条件	Sealed in dry,Store in freezer, under -20°C
体外研究	CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again.
体内研究	CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling. Animal Model: Forty female BALB/c mice aged 6-8 week old Dosage: 0.05 mg/kg Administration: Intratracheal administration; once per week; 90 days Result: CCG 63802 treatment in OVA +PGZ + CCG group significantly reduced RGS4 protein expression compared to OVA + PGZ group (P < 0.05)
危险品标志	T - 有毒物品
风险术语	25 - 吞食有毒。
安全术语	45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。

620112-78-9 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.22 ml	11.098 ml	22.197 ml
5 mM	0.444 ml	2.22 ml	4.439 ml
10 mM	0.222 ml	1.11 ml	2.22 ml
5 mM	0.044 ml	0.222 ml	0.444 ml

最后更新：2024-01-02 23:10:35