(1R, 2S) -N- [ (1,1-dimethylethoxy) carbonyl] -3-methyl-L-valinyl- (4R) -4- [ (7-chloro-4-methoxy-1-isoquinolinyl) oxy] -L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-vinylcyclopropylcarboxyl
630420-16-5
(1R, 2S) -N- [ (1,1-dimethylethoxy) carbonyl] -3-methyl-L-valinyl- (4R) -4- [ (7-chloro-4-methoxy-1-isoquinolinyl) oxy] -L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-vinylcyclopropylformamide (Asunaprevir)
CAS: 630420-16-5
化学式: C35H46ClN5O9S
<"" ="xl" "">| Chinese name | (1R, 2S) -N- [ (1,1-dimethylethoxy) carbonyl] -3-methyl-L-valinyl- (4R) -4- [ (7-chloro-4-methoxy-1-isoquinolinyl) oxy] -L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-vinylcyclopropylformamide |
| English name | Asunaprevir |
| alias | Aspirivir assurevir Arapivir Apinavir (1R, 2S) -N- [ (1,1-dimethylethoxy) carbonyl] -3-methyl-L-valinyl- (4R) -4- [ (7-chloro-4-methoxy-1-isoquinolinyl) oxy] -L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-vinylcyclopropylformamide |
| English alias | BMS650032 BMS-650032 BMS 650032 Asunaprevir BMS 650032 Asunaprevir API Asunaprevir (BMS-650032) (1R,2S)-N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenylcyclopropanecarboxamide 3-Methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-vinylcyclopropyl}-L-prolinamide Cyclopropanecarboxamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)- L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-L-valyl-4-[(7-chloro-4-methoxy-1-isoquinolinyl)oxy]-N-[(1R,2S)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethenylcyclopropyl]-, (4R)- tert-butyl N-[(2S)-1-[(2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yl)oxy-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)pyrrolidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate |
| CAS | 630420-16-5 |
| EINECS | 681-328-7 |
| chemical formula | C35H46ClN5O9S |
| molecular weight | 748.29 |
| InChI | InChI=1S/C35H46ClN5O9S/c1-9-19-16-35(19,31(44)40-51(46,47)22-11-12-22)39-28(42)25-15-21(49-29-24-14-20(36)10-13-23(24)26(48-8)17-37-29)18-41(25)30(43)27(33(2,3)4)38-32(45)50-34(5,6)7/h9-10,13-14,17,19,21-22,25,27H,1,11-12,15-16,18H2,2-8H3,(H,38,45)(H,39,42)(H,40,44)/t19-,21-,25+,27-,35-/m1/s1 |
| density | 1.37 |
| melting point | 149-150oC |
| solubility | DMSO (slightly soluble), methanol (slightly soluble, heated) |
| acidity coefficient | 4.49±0.40(Predicted) |
| storage conditions | -20°C Freezer, Under inert atmosphere |
| appearance | solid |
| color | White to Off-White |
630420-16-5 - introduce
Asunaprevir (BMS-650032) is a potent hepatitis C virus (HCV) NS3 protease inhibitor.Last Updated: 2022-10-16 17:27:30630420-16-5 - brief introduction
(1R, 2S) -N- [ (1,1-dimethylethoxy) carbonyl] -3-methyl-L-valinyl- (4R) -4- [ (7-chloro-4-methoxy-1-isoquinolinyl) oxy] -L-prolyl-1-amino-N- (cyclopropylsulfonyl) -2-vinylcyclopropylformamide is an organic compound, the following is a detailed description of it:Nature:
Appearance: The compound is a solid substance.
- Configuration: (1R, 2S) and (4R) stereoisomers
Solubility: Soluble in some organic solvents such as dimethyl sulfoxide and dimethyl formamide.
Purpose:
Production method:
The specific method for preparing the compound can be carried out according to relevant literature reports or by organic synthesis.
Safety information:
- Specific data on the safety and toxicity of this compound may be limited, and there is currently no detailed safety evaluation. When using or handling this compound, it is necessary to strictly follow the safety operating procedures of the chemical laboratory and take necessary protective measures, such as wearing protective glasses and gloves, and ensuring good ventilation conditions.
Last Updated: 2024-04-09 20:48:19
