毛壳素;毛壳素;28097-03-2;

2026-03-27 10:24:45

化学性质

属性
密度
1.8700
存贮条件
储存温度2-8°C
描述
产品介绍
Chaetocin, a natural product originally produced by Chaetomium species, is shown to have apoptotic effects on some cancer cells. Mechanistic studies show that chaetocin is taken up in the cells by a process that requires intact/unreduced disulfides for uptake. Once inside, this compound imposes oxidative stress and consequent apoptosis induction. Other studies have shown chaetocin to reduce lysine-specific histone methyltransferase effects of SUV39H, which play a key role in maintaining stable gene expression patterns during embryonic development and cellular differentiation. Additionally, this agent is reported to cause profound chromatin reorganization in fibroblast nuclei by inducing chromatin condensation/clustering. Consequentially, chaetocin impairs Trx (thioredoxin) systems, which are essential for deoxynucleotide synthesis and involved in a broad range of cellular functions. Chaetocin is an inhibitor of G9a, SUV39H1 and TrxR1.
别名
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密度：1.9±0.1 g/cm³

分子式：C30H28N6O6S4

分子量：696.840

精确质量：696.095337

PSA ：246.96000

LogP ：3.10

折射率：1.930

危险属性

标识符号 GHS07

信号词
Warning
风险声明 (欧洲) 20/21/22

警示性声明 P280

危害码（欧洲） Xn

危害声明 H302,H312,H332

个人防护设备
dust mask type N95 (US),Eyeshields,Gloves
RTECS
FM3032000
WGK德国
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符号：GHS07

信号词： Warning

危害声明：H302 + H312 + H332

警示性声明：P280

个人防护装备： dust mask type N95 (US); Eyeshields; Gloves

危害码 (欧洲) ：Xn

风险声明 (欧洲) ：20/21/22

危险品运输编码：UN 1544

RTECS号：FM3032000

包装等级：III

危险类别：6.1(b)