CP-424,174,英文名:CP-424,174,CAS:210825-31-3,CP-424174 is a cytokine release inhibitory drug (CRID) (IC
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最后更新：2024-01-02 23:10:35
210825-31-3
CP-424,174(CP-424,174)
CAS: 210825-31-3
化学式: C22H29ClN2O4S
| 中文名 | CP-424,174 |
| 英文名 | CP-424,174 |
| 别名 | 化合物CP 424174 N-((4-氯-2,6-二异丙基苯基)氨基甲酰基)-3-(2-羟基丙烷-2-基)苯磺酰胺 |
| 英文别名 | CP-424,174 N-((4-Chloro-2,6-diisopropylphenyl)carbamoyl)-3-(2-hydroxypropan-2-yl)benzenesulfonamide N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide Benzenesulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)- |
| CAS | 210825-31-3 |
| 化学式 | C22H29ClN2O4S |
| 分子量 | 452.99 |
| 密度 | 1?+-.0.06 g/cm3(Predicted) |
| 溶解度 | 溶于DMSO |
| 酸度系数 | 4.67±0.10(Predicted) |
| 存储条件 | room temp |
| 外观 | 粉末 |
| 颜色 | white to beige |
| 产品用途 | CP-424174 is a cytokine release inhibitory drug (CRID) (IC50 = 210 nM).CP-424174 inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes. |
| 参考资料 展开查看 | 1: Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J,Griffiths R, Dombroski MA, Gabel CA. Identification and characterization of anovel class of interleukin-1 post-translational processing inhibitors. JPharmacol Exp Ther. 2001 Oct;299(1):187-97. PubMed PMID: 11561079. 2: Perregaux DG, Bhavsar K, Contillo L, Shi J, Gabel CA. Antimicrobial peptidesinitiate IL-1 beta posttranslational processing: a novel role beyond innateimmunity. J Immunol. 2002 Mar 15;168(6):3024-32. PubMed PMID: 11884475. |
210825-31-3 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.208 ml | 11.038 ml | 22.075 ml |
| 5 mM | 0.442 ml | 2.208 ml | 4.415 ml |
| 10 mM | 0.221 ml | 1.104 ml | 2.208 ml |
| 5 mM | 0.044 ml | 0.221 ml | 0.442 ml |
