二异丙基氨基锂溶液（LDA）是具位阻的非亲核性强碱，可从从活性炭中提取氢。它可以在四氢呋喃存环境中由二异丙胺和丁基锂制备。 应用 二异丙基氨基锂可用于从含羰基的化合物中生成碳负离子或烯酸盐阴离子。 也可用作底物： 酮类的直接烷基化和酰化。 羟醛缩合反应。 α硒化反应。 从羰基化合物合成α, β- 不饱和羰基化合物。 酸、酯、酰胺和腈的烃化。 引发阴离子聚合。 Lithium diisopropylamide (LDA) is a hindered non-nucleophilic strong base that abstracts hydrogen from active carbon. It can be prepared from diisopropylamine and butyllithium in the presence of tetrahydrofuran. Application Lithium diisopropylamide can be used for the generation of carbanion or enolate anions from carbonyl group-containing compounds. It can also be used as a base in: The direct alkylation and acylation of ketones. The aldol condensation reaction. α-Selenation reaction. The synthesis of α, β- unsaturated carbonyl compounds from carbonyl compounds. The alkylation of acids, esters, amides, and nitriles. The initiation of anionic polymerization.
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Lithium diisopropylamide solution（LDA）
Dangerous GoodsCAS number：4111-54-0(Solution) molecular formula：C6H14LiN
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | L0171 | lithium N,N-diisopropylamide | DIISOPROPYLAMINE LITHIUM SALT [MI] | diisopropylamino lithium | OL028KIW1I | Lithium diisopropylamide | ||
| CAS number | 4111-54-0(Solution) | molecular formula | C6H14LiN |
| molecular weight | 107.12 g/mol | Exact mass | 2M in THF/n-hexanes |
| PSA | - | logp | - |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS08 , GHS09 , GHS05 , GHS07 , GHS02
Signal word：
危险
Hazard Statement：
H335: 可能引起呼吸道刺激 H351: 怀疑引起遗传缺陷 H373: 通过长时间或反复暴露对器官造成损害 H314: 造成严重的皮肤灼伤和眼睛损伤 H225: 高度易燃的液体和蒸气 H336: 可能引起嗜睡或头晕 H303: 要是吞了可能有害 H410: 对水生生物有剧毒并具有长期持续影响 H304: 吞咽并进入呼吸道可能致命
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P301+P310: 如误吞咽：立即呼叫急救中心/医生。 P210: 远离热源，热表面，火花，明火和其他点火源。 - 禁止抽烟。 P310: 立即致电解毒中心或医生。 P312: 打电话给毒物中心或医生。。。如果你觉得不舒服 P303+P361+P353: 如皮肤（或头发）沾染：立即脱掉所有沾染的衣
UN Number：
2924
Packing Group：
II
Production methods and uses
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MSDS
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