N-(3-Oxohexanoyl)-L-homoserine lactone (OHHL; N-(3-Oxohexanoyl)homoserine lactone) 是一种 LuxR 型转录因子 CarR 的特异性激动剂，Kd 为 1.8 μM。N-(3-Oxohexanoyl)-L-homoserine lactone 通过诱导蛋白多聚化激活 CarR，促进其与 carR-carA 基因间区的靶 DNA 序列结合，进而上调碳青霉烯生物合成基因的转录。N-(3-Oxohexanoyl)-L-homoserine lactone 作为群体感应信号分子，使细菌能够以细胞密度依赖的方式协调碳青霉烯抗生素的产生。N-(3-Oxohexanoyl)-L-homoserine lactone 用于细菌群体感应机制研究，尤其是胡萝卜软腐欧文氏菌和小肠结肠炎耶尔森氏菌的次级代谢及毒力因子调控通路的研究。 N-(3-Oxohexanoyl)-L-homoserine lactone (OHHL; N-(3-Oxohexanoyl)homoserine lactone) is a specific agonist of LuxR-type transcription factor CarR with a Kd of 1.8 μM. N-(3-Oxohexanoyl)-L-homoserine lactone activates CarR by inducing protein multimerization, promoting its binding to target DNA sequences in the carR-carA intergenic region, thereby upregulating the transcription of carbapenem biosynthesis genes. N-(3-Oxohexanoyl)-L-homoserine lactone acts as a quorum sensing signal molecule, enabling bacteria to coordinate the production of carbapenem antibiotics in a cell density-dependent manner. N-(3-Oxohexanoyl)-L-homoserine lactone is used to study bacterial quorum sensing mechanisms, especially the secondary metabolism and virulence factor regulatory pathways of Erwinia carotovora and Yersinia enterocolitica.
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N-(Ketocaproyl)-L-homoserine Lactone
Dangerous GoodsCAS number：143537-62-6 molecular formula：C10H15NO4
overview
compound introduction
Specs
| Chinese alias | N-(3-氧代己酰)-L-高丝氨酸内酯 | N-(β-酮己酰)-L-高丝氨酸内酯 | ||
| English alias | N-(beta-Ketocaproyl)-L-homoserine lactone | N-(3-Oxohexanoyl)-L-homoserine lactone | N-(beta-Ketocaproyl)-DL-homoserine lactone | ||
| CAS number | 143537-62-6 | molecular formula | C10H15NO4 |
| molecular weight | 213.23 g/mol | Exact mass | - |
| PSA | 72.500 Ų | logp | 0.900 |
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physicochemical properties
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Safety information
WGK Germany：
3
Personal protective equipment：
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
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MSDS
Found 1 shareMSDS
143537-62-6 | N- (β-Ketocaproyl) -L-homoserine lactone | N- (β-Ketocaproyl) -L-homoserine lactone
