Information Daclatasvir Dihydrochloride Daclatasvir is an orally available antiviral agent that inhibits the NS5A region of the hepatitis C virus (HCV) used for the treatment of chronic HCV genotype 1 and 3 infection. Targets NS5A In vitro Daclatasvir exhibited potent inhibition in all of the wild-type replicons and hybrid replicons representing the range of genotypes and subtypes. daclatasvir induces an alteration in the subcellular localization of NS5A, which inhibits the formation and activation of HCV RCs. Daclatasvir was found to have a high potency across all HCV genotypes with half-maximum effective concentrations (EC50) ranging from 9 to 146 pM. While it is pangenotypic, it has a low barrier to resistance against the subtype of Genotype 1a. In vivo Daclatasvir has good bioavailability in rats, dogs and cynomolgus monkey (F%= 50, 108 and 38 respectively).
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Daclatasvir Dihydrochloride
Dangerous GoodsCAS number：1009119-65-6 molecular formula：C40H50N8O6.2HCl
overview
compound introduction
Specs
| Chinese alias | 盐酸达拉他韦 | ||
| English alias | CHEBI:83800 | Daclatasvir Digydrochloride | s5062 | Daklinza | Dimethyl N,N'-((1,1'-biphenyl)-4,4'-diylbis(1H-imidazole-5,2-diyl-((2S)-pyrrolidine-2,1-diyl)((1S)-3-methyl-1-oxobutane-1,2-diyl)))dicarbamate dihydrochloride | MFCD25541736 | CCG-270504 | Dak | ||
| CAS number | 1009119-65-6 | molecular formula | C40H50N8O6.2HCl |
| molecular weight | 811.8 g/mol | Exact mass | 10mM in DMSO |
| PSA | 175.000 Ų | logp | 5.812 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS08 , GHS07
Signal word：
Warning
Hazard Statement：
H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H373: 通过长时间或反复暴露对器官造成损害 H317: 可能引起皮肤过敏反应
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P271: 仅在室外或通风良好的地方使用。 P304+P34
Production methods and uses
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MSDS
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