CAS number：118974-02-0 molecular formula：C22H25N3O3
Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3.2 colon carcinoma cells. Fumitremorgin C reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1).
| Chinese alias | 烟酸甲酯 | ||
| English alias | (5as,12s,14as)-9-methoxy-12-(2-methylprop-1-en-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5h,14h-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione | F85534 | AKOS024457321 | SCHEMBL13113871 | SMR003082520 | HY-N2143 | fumitremorgin-c | (1S | ||
| CAS number | 118974-02-0 | molecular formula | C22H25N3O3 |
| molecular weight | 379.45 g/mol | Exact mass | ≥95% |
| PSA | 65.600 Ų | logp | 3.000 |
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