compound introduction
NSC 23766是一种Rac GTPase抑制剂，通过鸟嘌呤核苷酸因子(GEFs)靶向作用于Rac 活化，无细胞试验中IC50为~50 μM；但是不会抑制密切相关的靶点，Cdc42或RhoA。 Rac1-GEF相互作用的选择性抑制剂NSC23766 三盐酸盐已被用作 ras 相关的 C3 肉毒毒素底物 1 (RAC1) 抑制剂。
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NSC 23766
Dangerous GoodsCAS number：1177865-17-6 molecular formula：C24H35N7·3HCl
overview
Specs
| Chinese alias | N6- [2-(4-二乙氨基-1-甲基-丁氨基)-6-甲基-嘧啶-4-基]-2-甲基-喹啉-4,6-二胺 三盐酸盐 | ||
| English alias | NSC23766 trihydrochloride | UNM-0000305815 | BN162673 | CCG-265031 | EX-A3156 | NSC23766 3HCl salt | NSC 23766 trihydrochloride | N6-(2-((5-(Diethylamino)pentan-2-yl)amino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine trihydrochloride | NCGC00092 | ||
| CAS number | 1177865-17-6 | molecular formula | C24H35N7·3HCl |
| molecular weight | 530.96 g/mol | Exact mass | ≥98% |
| PSA | 92.000 Ų | logp | - |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
WGK Germany：
3
Production methods and uses
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MSDS
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