TRAF-STOP inhibitor 6877002，一种抑制 CD40-TRAF6 相互作用的选择性抑制剂，从专利 WO2014033122A1 中获得，抑制 RAW 细胞中 NF-κB 活化，化合物VII。TRAF-STOP 6877002 可阻止小鼠中已发生的动脉粥样硬化恶化，减少白细胞募集并减少巨噬细胞活化；减少动脉粥样硬化斑块中的巨噬细胞增殖。 Product Application： CD40-TRAF6 signaling inhibitor has been used to treat human embryonic kidney (HEK)-293T cells to test its inhibitory effect on the tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) leading to subsequent abrogation of (P2RY6)-dependent nuclear factor kappa B (NF-κB). Product Description： TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques.
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Compound 6877002
Dangerous GoodsCAS number：433249-94-6 molecular formula：C17H17NO
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compound introduction
Specs
| Chinese alias | 3-[(2,5-二甲基苯基)氨基]-1-苯基-2-丙烯-1-酮 | ||
| English alias | F6176-1973 | (2E)-3-[(2,5-DIMETHYLPHENYL)AMINO]-1-PHENYLPROP-2-EN-1-ONE | AKOS027470222 | 3-((2,5-Dimethylphenyl)amino)-1-phenylprop-2-en-1-one | TRAF-STOP inhibitor 6877002 | AKOS040742773 | CD40-TRAF6 inhibitor | SCHEMBL15614836 | (E)-3-((2,5-dimethylph | ||
| CAS number | 433249-94-6 | molecular formula | C17H17NO |
| molecular weight | 251.32 g/mol | Exact mass | ≥98% |
| PSA | 29.100 Ų | logp | 4.700 |
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Safety information
pictogram：
GHS09
Hazard Statement：
H411: 对水生生物有毒并具有长期持续影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物
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