CAS number：1346546-69-7 molecular formula：C19H17N3O2S2
GSK'872 (GSK2399872A)是一种有效的、特异性的RIP3 kinase抑制剂，与RIP3激酶区域以高亲和力结合（IC50为1.8 nM），抑制酶活性的IC50为1.3 nM。仅具微弱交叉反应。 GSK'872 is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.
| Chinese alias | N-(6-丙-2-基磺酰基喹啉-4-基)-1,3-苯并噻唑-5-胺 | N-(6-(异丙基磺酰基)喹啉-4-基)苯并[d]噻唑-5-胺 | RIPK3抑制剂 | ||
| English alias | GSK′872 | N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine | ||
| CAS number | 1346546-69-7 | molecular formula | C19H17N3O2S2 |
| molecular weight | 383.48 g/mol | Exact mass | - |
| PSA | 109.000 Ų | logp | 4.200 |
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