Necrostatin-5

Dangerous Goods

CAS number：337349-54-9 molecular formula：C19H17N3O2S2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Product Introduction Necrostatin-5 is an inhibitor of necroptosis (non-apoptotic cell death pathway) by indirect inhibition of RIP1 kinase. Necroptosis is defined as alternative active cell death pathway: Death-Domain Receptor (DRs, e.g. Fas/TNFR) mediated and caspase-inhibitor insensitive with specific morphology (nuclear condensation, organelle swelling, loss of plasma membrane integrity). The necrostatins have been discovered to inhibit this pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved: T-loop dependent inhibition by necrostatin-1 partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5, since necrostatin-5 is a potent inhibitor of immunnoprecipitated RIP1, but does not inhibit recombinant RIP1. Application Necrostatin-5 is an inhibitor of necroptosis by indirect inhibition of RIP1 kinase

Specs

Chinese alias	2-[[[3-(4-甲氧基苯基)-4-氧代-5,6,7,8-四氢-[1]苯并硫代[2,3-d]嘧啶-2-基]硫烷基]乙腈
English alias	STL304760 \| SCHEMBL12682848 \| Necrostatin-5, >=98% (HPLC), solid \| AKOS000510375 \| Oprea1_213608 \| Oprea1_435788 \| HMS595K16 \| 2 [[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2, 3- d]pyrimidin-2-yl]thio]-acetonitrile \| ChemDiv1_003052 \|
CAS number	337349-54-9	molecular formula	C19H17N3O2S2
molecular weight	383.49 g/mol	Exact mass	≥98%
PSA	119.000 Å²	logp	4.400

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H319: 引起严重眼睛刺激 H413: 可能对水生生物造成长期的有害影响

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。