AZD0156 是有效的、选择性的ATM激酶抑制剂，具有潜在的化疗/辐射增敏和抗肿瘤活性。AZD0156 可防止DNA损伤检查点激活，破坏DNA损伤修复，诱导肿瘤细胞凋亡，并导致过表达ATM的肿瘤细胞死亡。 Information AZD0156 is a potent and selective inhibitors ofATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD0156 prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. Targets ATM In vitro AZD0156 shows sub-nanomolar potency in cell based assays of ATM inhibition with selectivities of greater than 1000 fold over other members of the PIKK family of enzymes. In vivo AZD0156 is a permeable, highly soluble compound with excellent preclinical pharmacokinetic properties including oral bioavailability. AZD0156 shows robust efficacy in mouse xenograft models after oral administration when combined with DSB inducing agents. AZD0156 is currently undergoing early clinical assessment.
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AZD0156
Dangerous GoodsCAS number：1821428-35-6 molecular formula：C26H31N5O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 1821428-35-6 | 8-(6-(3-(Dimethylamino)propoxy)pyridin-3-yl)-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one | BENZENEMETHANOL, .ALPHA.-((1S)-1-AMINOETHYL)-, (.ALPHA.S)- | HYDROCHLORIDE EPINEPHRINE | MFCD30470661 | AZD0156 | ||
| CAS number | 1821428-35-6 | molecular formula | C26H31N5O3 |
| molecular weight | 461.56 g/mol | Exact mass | - |
| PSA | 71.000 Ų | logp | 2.900 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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