CAS number：1415800-43-9 molecular formula：C32H43N5O2
产品介绍： UNC1215是L3MBTL3的有效的抑制剂，其对L3MBTL3的抑制强度比MBT家族其他成员更强。HEK293细胞转染了L3MBTL3的3 MBT区域的GFP融合蛋白后，用UNC1215处理可以减少剂量依赖性的反应时间通过结合和与L3MBTL3的共定位。通过AlphaScreen○R甲基化组蛋白肽竞争分析，UNC1215对L3MBTL3显示出较高的拮抗能力，IC50值为24±7.6 nM。作为甲基赖氨酸阅读蛋白L3MBTL3的第一个有效的，选择性的抑制剂，UNC1215通过拮抗L3MBTL3单或双甲基赖氨酸阅读功能显示出高度选择性。 UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family.
| Chinese alias | - | ||
| English alias | BP-21087 | GTPL8232 | SB19337 | AS-16797 | UNC1215, >=98% (HPLC) | 2-Phenylamino-1,4-bis(4-(pyrrolidinyl)piperidinyl)benzamide | UNC1215 | UNC-1215 | Butanoic acid, 2-amino-4-(methylsulfonyl)-, (.+/-.)- | EX-A193 | CCG-269911 | MFCD22683289 | HMS3426E15 | | ||
| CAS number | 1415800-43-9 | molecular formula | C32H43N5O2 |
| molecular weight | 529.72 g/mol | Exact mass | - |
| PSA | 59.100 Ų | logp | 5.100 |
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