CTB

Dangerous Goods

CAS number：451491-47-7 molecular formula：C16H13ClF3NO2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

CTB is a potent p300 histone acetyltransferase activator CTB can effectively induce apoptosis in MCF-7 cells . In Vitro CTB (10, 50, 100, 150, 200, and 250 μM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. ? CTB (0-200 μM; 24 hours) inhibits the viability of MCF-7 cells with an IC 50 of 85.43 μM. ? CTB (85.43 μM; 24, 48 and 72 h) induces time dependence apoptosis of MCF-7 cells. ? CTB (50 uM; 24?h) increases p300/CBP activity , and reduces autophagic flux in primary neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cell Concentration: 0-200 μM Incubation Time: 24 hours Result: Inhibit viability with an IC 50 of 85.43 μM. Apoptosis AnalysisCell Line: MCF-7 cell Concentration: 85.43 μM Incubation Time: 24, 48 and 72 h Result: Iinduced time-dependence apoptosis. Form:Solid IC50& Target:CBP/p300

Specs

Chinese alias	-
English alias	CTB \| DTXSID401016272 \| MS-25265 \| STL229939 \| Cholera Toxin B Subunit \| N-(4-chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide \| Cholera Toxin B subunit, FITC conjugate, lyophilized powder \| HMS3426C07 \| YDXZSNHARVUYNM-UHFFFAOYSA-N \| N-[4-chloro-3-(tri
CAS number	451491-47-7	molecular formula	C16H13ClF3NO2
molecular weight	343.73 g/mol	Exact mass	≥99%
PSA	38.300 Å²	logp	4.600

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS09 , GHS07

Signal word：

Warning

Hazard Statement：

H319: 引起严重眼睛刺激 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P391: 收集溢出物 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。

WGK Germany：