Colipase

在处于或高于胆酸盐临界胶束温度时，所制备的几乎不 含共脂肪酶的胰脂肪酶在与胆酸盐结合后会被强烈抑制。 共脂肪酶的加入恢复了受胆酸盐抑制的脂肪酶的活性， 凝胶过滤实验表明，在胆盐溶液中，共脂肪酶与脂肪酶形 成 1:1 复合物的二聚体。 【产品特性】 脂肪酶和共脂肪酶以化学计量关系相互作用，并将共脂肪酶相互作用（所产生的酶）归类为脂肪酶的辅酶。共脂肪酶是一种分子量约 11000 的单链多肽，具有 5 个二硫键、等电点 5.0 。 【用途和作用】 在诊断试验中使用共脂肪酶作为共乳化剂，结合生色脂肪酶底物测定脂肪酶活性。 【注意事项】 为了您的安全和健康，请穿实验服并戴一次性手套操作。 Pancreatic lipase when prepared essentially free of colipase is strongly inhibited by conjugated bile salts at or above their critical micell concentration. Addition of colipase restores activity to the bile-salt-inhibited lipase and gel filtration experiments indicate that colipase in bile salt solution makes a dimer which forms a 1:1 complex with lipase. 【Properties】 Lipase and colipase interact as a stoichiometrical relationship and classified colipase interact as a co-enzyme for lipase. The colipase is a single chain polypeptide with a molecular weight approximately 11,000 with 5 disulfide bridges and isoelectric point 5.0. 【Application】 Use Colipase as a co-emulslfier in diagnostic tests for the determination of lipase activity in combination with chromogenic Lipase Substrate. 【Attention】 For your safety and health, please wear Lab coat and disposable gloves.

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