BL-1249 是一种非甾体抗炎剂 (NSAID) 和钾通道激活剂，可有效激活 K2P2.1 (TREK-1) 和 K2P10.1 (TREK-2)，EC50 值分别为 5.5 μM 和 8.0 μM。BL-1249 在细胞外激活了所有 TREK 亚家族成员，但对其他 K2P 亚家族没有影响。BL-1249 对膀胱的选择性 (EC50 为 1.26 μM) 比对血管组织 (EC50 为 21.0 μM) 更高。 BL-1249 is a nonsteroidal anti-inflammatory agent (NSAID) and a potassium channel activator. BL-1249 potently activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2) with EC50 values of 5.5 μM and 8.0 μM, respectively. BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K2P subfamilies. BL-1249 exhibits more selective for the bladder (EC50 of 1.26 μM) than vascular tissue (EC50 of 21.0 μM). Application： BL-1249 has been used: as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line as a TREK1 and TREK2 activator in mice.
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BL 1249
Dangerous GoodsCAS number：18200-13-0 molecular formula：C17H17N5
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine | J-011649 | EX-A7623 | N-[2-(2H-tetrazol-5-yl)phenyl]-5,6,7,8-tetrahydronaphthalen-1-amine | 1-Naphthalenamine, 5,6,7,8-tetrahydro-N-(2-(1H-tetrazol-5-yl)phenyl)- | SCHEMBL339107 | BL-12 | ||
| CAS number | 18200-13-0 | molecular formula | C17H17N5 |
| molecular weight | 291.35 g/mol | Exact mass | - |
| PSA | 66.500 Ų | logp | 4.100 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H413: 可能对水生生物造成长期的有害影响
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304
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MSDS
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