(Thr4,Gly7)-Oxytocin

(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K + channels. In Vitro (Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons. (Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells. (Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo (Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice . (Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Swiss Webster mice Dosage: 1 μM Administration: Intratracheal administration for 24 h Result: Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions. Form:Solid IC50& Target:OT receptors, K + channels

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