TRAM-34已被证明是人类T淋巴细胞中克隆和天然IK1通道的抑制剂。这些K+通道与细胞的过度增殖有关。抑制IK1通道已被证明可以根据TRAM-34的浓度调节细胞增殖。机制研究表明，TRAM-34可能导致细胞在G0/G1期停止生长。TRAM-34是一种选择性强的中间电导Ca2+激活K+通道（IKCa1，KCa3.1）抑制剂，Kd为20 nM，对其他离子通道的选择性为200至1500倍，并且不会阻断细胞色素P450。 TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase.TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450.
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TRAM-34
Dangerous GoodsCAS number：289905-88-0 molecular formula：C22H17ClN2
overview
compound introduction
Specs
| Chinese alias | 1-[(2-氯苯基)二苯甲基]-1H-吡唑 | ||
| English alias | NCGC00165909-03 | SureCN41130 | 1-[(2-chlorophenyl)-di(phenyl)methyl]pyrazole | HMS3748M21 | 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole | Triarylmethane-34 | J-017347 | CHEBI:34990 | HB1058 | BCP01324 | HY-13519 | EX-A2316 | MFCD09842562 | s1160 | AC- | ||
| CAS number | 289905-88-0 | molecular formula | C22H17ClN2 |
| molecular weight | 344.84 g/mol | Exact mass | - |
| PSA | 17.800 Ų | logp | 5.600 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US), Eyeshields, Gloves
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MSDS
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