E-64是一种亲和纯化半胱氨酸蛋白酶的有效配体。当耦合到硫基化的亲和基质时，结合不再是不可逆的，但保留特异性 E-64 is a cysteine protease inhibitor that was isolated from the mold Aspergillus japonicus TPR-64. E-64 is also known as N-[N-(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine. E-64 effectively inhibits various cysteine proteases, in particular: • cathepsin K • cathepsin L • cathepsin S E-64 also acts against other enzymes, such as: • calpain • cathepsin B • cathepsin H • papain protease inhibitor ，E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained E-64 is a cysteine protease inhibitor that was isolated from the mold Aspergillus japonicus TPR-64. E-64 is also known as N-[N-(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine. E-64 effectively inhibits various cysteine proteases, in particular: • cathepsin K • cathepsin L • cathepsin S E-64 also acts against other enzymes, such as: • calpain • cathepsin B • cathepsin H • papain application： It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained
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E-64
Dangerous GoodsCAS number：66701-25-5 molecular formula：C15H27N5O5
overview
compound introduction
Specs
| Chinese alias | 反-环氧丁二酰基-L-亮氨酰胺基(4-胍基)丁烷 | L-反-3-羧基环氧乙烷-2-羰基)-L-亮氨酰胍基丁胺 | N-(反式-环氧丁二酰基)-L-亮氨酸-胍基丁基酰胺 | ||
| English alias | SCHEMBL4740187 | BDBM50157741 | (2S,3S)-3-(N-{(S)-1-[N-(4-guanidinobutyl)carbamoyl]3-methylbutyl}carbamoyl)oxirane-2-carboxylic acid | AKOS016007415 | (2S,3S)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2 | ||
| CAS number | 66701-25-5 | molecular formula | C15H27N5O5 |
| molecular weight | 357.41 g/mol | Exact mass | 10mM in DMSO |
| PSA | 172.000 Ų | logp | -0.900 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS08
Signal word：
Warning
Hazard Statement：
H371: 可能会损坏器官
Statement of Preventive Measures：
P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P308+P316: 如果暴露或担心：立即寻求紧急医疗救助。
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
RR0390000
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 1 shareMSDS
66701-25-5 | 68305 MannheimDeutschland.pdf
