SB203580是一种p38 MAPK抑制剂，在THP-1细胞中IC50为0.3-0.5 μM，对SAPK3(106T)和SAPK4(106T)选择性低10倍，且阻断PKB磷酸化，IC50为3-5 μMMDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion. 16 It was used to inhibit MAPK signaling in mouse cortical neurons 17 and human hepatocellular carcinoma cell lines. 18 SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion. 16 It was used to inhibit MAPK signaling in mouse cortical neurons 17 and human hepatocellular carcinoma cell lines. 18
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SB-203580
Dangerous GoodsCAS number：152121-47-6 molecular formula：C21H16FN3OS
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compound introduction
Specs
| Chinese alias | - | ||
| English alias | ES-0013 | RWJ64809 | RWJ-64809 | CHEBI:90705 | UNII-OU13V1EYWQ | J-008891 | 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine | Prestwick3_001051 | RWJ 64809 | BCP01763 | HMS3244I15 | PYRIDINE, 4-(4-(4-FLUOROPHENYL)-2-(4-(METHYL | ||
| CAS number | 152121-47-6 | molecular formula | C21H16FN3OS |
| molecular weight | 377.43 g/mol | Exact mass | - |
| PSA | 77.900 Ų | logp | 3.200 |
numbering system
No numbering system information yet
physicochemical properties
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Safety information
pictogram：
GHS05 , GHS07
Signal word：
Danger
Hazard Statement：
H302: 吞食有害 H318: 造成严重的眼睛损伤
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
WGK Germany：
3
Personal protective equipment：
dust mask type N95 (US), Eyeshields, Gloves
Production methods and uses
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MSDS
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