Trifarotene

Dangerous Goods

CAS number：895542-09-3 molecular formula：C29H33NO4

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Trifarotene (CD5789) is a potent and selective RARγ agonist. Trifarotene (CD5789) shows ∼65-fold and ∼16-fold selectivitiy for the RARγ ( EC 50 =7.7 nM) over RARα ( EC 50 =500 nM) and RARβ ( EC 50 =125 nM), respectively. In Vitro Trifarotene (CD5789) (3.3 μL 0.33 cm 2 ; 24 hours) involves in keratinization, desquamation, cornification and cell adhesion in reconstructed human epidermis (RHE). The mean EC 50 on the combined target genes is 0.0048% for Trifarotene. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Trifarotene (0.001%-0.01% in a cream at 25 mg/mouse) shows dose-dependent comedolytic activity, being fully efficacious at 0.01% (98% reduction). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Rhino miceDosage: 0.001%, 0.0025%, 0.005% and 0.01% in a cream at 25 mg/mouse (5 cm 2 surface on the back skin on a 5 mg/cm 2 basis) Administration: Topical application; once a day; 11 days Result: Increased the epidermis thickness by 275% (66 μm) and the transepidermal water loss (TEWL) by 285% (26 g/h/m 2 ). Form:Solid

Specs

Chinese alias	三法罗汀
English alias	DTXCID80160272 \| Trifarotene \| BDBM50457548 \| (1,1':3',1''-TERPHENYL)-4-CARBOXYLIC ACID, 3''-(1,1-DIMETHYLETHYL)-4'-(2-HYDROXYETHOXY)-4''-(1-PYRROLIDINYL)- \| EX-A2704 \| Q27236856 \| D10AD06 \| GS-3516 \| PB48016 \| Trifarotene [USAN:INN] \| 4-[3-(3-tert-butyl-
CAS number	895542-09-3	molecular formula	C29H33NO4
molecular weight	459.6 g/mol	Exact mass	≥98%
PSA	70.000 Å²	logp	6.3

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS08 , GHS07

Signal word：

Warning

Hazard Statement：

H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H361: 怀疑破坏生育力或未出生的孩子 H362: 可能对母乳喂养的孩子造成伤害

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P271: 仅在室外或通风良