Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production.Chymostatin has been used in a study that determined that molecular calculations are useful for evaluating the interactions between ligands, including inhibitors and homologous enzymes, in docking models. Chymostatin has also been used in a study to investigate the norovirus protease as an attractive target for antiviral drμg development. Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production.
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Chymostatin
Dangerous GoodsCAS number：9076-44-2 molecular formula：C31H41N7O6
overview
compound introduction
Specs
| Chinese alias | N-(Nα-羰基-Cpd-X-Phe-al)-Phe(Cpd = 环氧环氧环己烷)(环氧环氧环己烷= [S,S]-α-(2-亚氨基六氢-4-嘧啶基)甘氨酸) | ||
| English alias | FT-0623815 | EINECS 257-382-9 | SCHEMBL14029469 | 2-[[1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[4-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid | L-2-(2-Amino-1,4,5,6-tetrahydr | ||
| CAS number | 9076-44-2 | molecular formula | C31H41N7O6 |
| molecular weight | 607.7 g/mol | Exact mass | - |
| PSA | 204.000 Ų | logp | 1.800 |
numbering system
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physicochemical properties
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Safety information
WGK Germany：
3
Personal protective equipment：
Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
RTECS：
GC3047700
Production methods and uses
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downstream information
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MSDS
Found 1 shareMSDS
9076-44-2 | 68305 MannheimDeutschland.pdf
