compound introduction
Ebelactone A是一种β-内酯酶抑制剂，首次从培养的土壤放线菌菌株中分离出来。它可以抑制细胞表面发现的酯酶、脂肪酶和N-甲酰蛋氨酸氨基肽酶（IC50分别为0.056、0.003和0.08µg/ml），这些酶已被证明可以刺激免疫细胞中的宿主防御。据报道，Ebelactone A还可以抑制真菌病原体产生的角质酶，从而显示出植物保护功能。 Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes. It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08 µg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells. Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function.
