一种天然止痛药，可分泌到人的唾液中。卵磷脂 对脑啡肽失活的表肽酶人类NEP（hNEP）和人类AP-N（hAP-N）表现出双重抑制作用。作为镇痛药，阿片吡啶比鸦片吗啡强6倍。卵磷脂 与大鼠唾液酸蛋白肽密切相关，后者是疼痛感知的抑制剂，并通过增强内源性微和δ阿片受体依赖性脑啡肽通路而起作用。在大鼠研究中，卵磷脂 抑制了化学诱导的炎症和急性身体疼痛的疼痛感。在这两种情况下，1 mg / kg的给药剂量均具有与3-6 mg / kg吗啡相同的止痛能力。 A natural analgesic that is secreted into human saliva. Opiorphin demonstrates dual-inhibitory potency on the enkephalin-inactivating ectopeptidases human NEP (hNEP) and human AP-N (hAP-N). As an analgesic, Opiorphin is 6 times stronger than the opiate morphine. Opiorphin is closely related to the rat sialorphin peptide, which is an inhibitor of pain perception and acts by potentiating endogenous micro- and δ-opioid receptor-dependent enkephalinergic pathways. In rat studies, Opiorphin suppressed pain sensation for both chemical-induced inflammation and acute physical pain. In both cases, the administered dose of 1 mg/kg provided the same painkilling power as 3-6 mg/kg of morphine.
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Opiorphin
Dangerous GoodsCAS number：864084-88-8 molecular formula：C29H48N12O8
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| Chinese alias | - | ||
| English alias | L-Glutaminyl-L-arginyl-L-phenylalanyl-L-seryl-L-arginine | CHEBI:177467 | DTXSID901027119 | HY-W345510 | GTPL11538 | Opiorphin | D93123 | (2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,5-diamino-5-oxopen | ||
| CAS number | 864084-88-8 | molecular formula | C29H48N12O8 |
| molecular weight | 692.77 g/mol | Exact mass | - |
| PSA | 372.000 Ų | logp | -7.000 |
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