Enniatin B

Dangerous Goods

CAS number：917-13-5 molecular formula：C33H57N3O9

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Enniatin B是离子载体抗生素和多种菌株产生的真菌代谢产物。研究表明，Enniatin B在体外具有细胞毒性活性，但没有遗传毒性活性。烯属蛋白B已显示出抑制酿酒酵母中的Pdr5p ABC转运蛋白以及酰基-CoA-胆固醇酰基转移酶（ACAT）。此外，对缬氨霉素和烯尿素B的联合研究表明，它们可以与钙调蛋白（CaM）结合并抑制3'，5'-环核苷酸磷酸二酯酶（PDE）的活性。可以认为，enniatin B具有抗癌特性。 Enniatin B is an ionophore antibiotic and fungal metabolite generated by multiple|Fusarium|strains. Studies indicate that Enniatin B has cytotoxic activity|in vitro|, but no genotoxic activity. Enniatin B has been shown to inhibit the Pdr5p ABC transporter in|Saccharomyces cerevisiae|, as well as acyl-CoA-cholesterol acyltransferase (ACAT). Additionally, joint studies of valinomycin and enniatin B have demonstrated that they can bind to calmodulin (CaM) and inhibit the activity of 3',5'-cyclic nucleotide phosphodiesterase (PDE). It is believed that enniatin B possess anticancer properties.

Specs

Chinese alias	-
English alias	HMS2269N19 \| MEGxm0_000284 \| CHEBI:64649 \| (3S,6R,9S,12R,15S,18R)-4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone \| 2,8,14-Triaza-3,6,9,12,15,18-hexakis(methylethyl)-2,8,14-trimethyl-5,1
CAS number	917-13-5	molecular formula	C33H57N3O9
molecular weight	639.82 g/mol	Exact mass	-
PSA	140.000 Å²	logp	6.500

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS06

Signal word：

Danger

Hazard Statement：

H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良

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